QUANTITATIVE ASSESSMENT OF HUMAN COCHLEAR FUNCTION BY EVOKED OTOACOUSTIC EMISSIONS
QUANTITATIVE ASSESSMENT OF HUMAN COCHLEAR FUNCTION BY EVOKED OTOACOUSTIC EMISSIONS
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DOI：
10.1016/0378-5955(91)90191-b
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发表时间：
1991-03-01
期刊：
影响因子：
2.8
通讯作者：
TROTOUX, J
中科院分区：
文献类型：
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作者：
AVAN, P;BONFILS, P;TROTOUX, J
本文测定了44例正常青年人和118例声损伤和老年性聋两类耳蜗功能障碍患者的诱发性耳声发射（EOE）幅度及其检测阈值。每个类别使用不同的方法：检测点击EOE或刺激频率发射。对两组结果进行偏相关和多变量分析，以探讨EOE阈值与纯音听阈（250 - 8000 Hz）之间的关系。只有一个显著的相关性，线性相关EOE阈值和听力阈值在2kHz（P < 0.001），独立于耳蜗功能障碍的起源。这表明EOE阈值不是频率特异性的，因为阈值处的EOE频率几乎总是接近1 kHz。提出了一个简单的模型，假设EOE振幅和阈值是成比例的剩余的活性位点的总数在Corti器官，即活性基底膜的总长度。结果表明，该模型解释了统计分析所揭示的结果，并与实验数据相拟合。它可用于定量预测患者的残余耳蜗活动。然而，EOE阈值仅对已经重要的耳蜗改变敏感，并且该参数似乎不允许对耳蜗功能障碍的早期阶段进行随访。
The amplitudes of evoked otoacoustic emissions (EOE) and their detection threshold were measured in 44 normal young adults and 118 patients with two categories of cochlear dysfunction, acoustic trauma and presbycusis. A different method was used for each category: detection of click EOE or of stimulus frequency emissions. A partial correlation and multivariate analysis was performed for both groups of results to investigate the relations between EOE threshold and pure tone audiometric thresholds (250 to 8000 Hz). Only one significant correlation was found, linearly relating EOE threshold and hearing threshold at 2 kHz (P < 0.001), independently of the origin of cochlear dysfunction. It suggests that EOE threshold is not frequency-specific since the frequency of EOE at threshold was nearly always close to 1 kHz. A simple model is proposed, based on the assumption that EOE amplitudes and threshold are proportional to the total number of residual active sites in the organ of Corti, i.e. to the total length of active basilar membrane. It is shown that this model accounts for the results disclosed by the statistical analysis and fits the experimental data. It can be used for quantitatively predicting the residual cochlear activity of a patient. However, the EOE threshold is only sensitive to already important cochlear alterations and this parameter does not seem to allow a follow-up of early stages of cochlear dysfunction.