The diagnosis of interstitial cystitis revisited: Lessons learned from the National Institutes of Health Interstitial Cystitis Database study
The diagnosis of interstitial cystitis revisited: Lessons learned from the National Institutes of Health Interstitial Cystitis Database study
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DOI：
10.1016/s0022-5347(01)61948-7
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发表时间：
1999-02-01
影响因子：
6.6
通讯作者：
Nyberg, L
中科院分区：
文献类型：
--
作者：
Hanno, PM;Landis, JR;Nyberg, L
目的：间质性膀胱炎缺乏准确的工作定义可能导致临床医生事实上使用国家糖尿病、消化和肾脏疾病研究所(NIDDK)的“研究”定义。我们根据间质性膀胱炎数据库研究中评估的患者的更广泛的纳入标准来评估这些严格的标准，以确定它们在临床实践中作为间质性膀胱炎诊断的有用基础的实用性。材料和方法：共有379名在1996年1月1日之前完成间质性膀胱炎数据库筛查的妇女符合尿频、尿急或疼痛的基本标准，持续至少6个月，但没有可诊断的病因。在这些患者中，148人接受了膀胱镜检查和膀胱积液扩张作为评估的一部分。对所有患者进行至少1年的随访。将临床诊断为间质性膀胱炎的患者与符合NIDDK研究定义的间质性膀胱炎的患者进行比较。结果：几乎90%潜在符合NIDDK标准的患者被经验丰富的临床医生认为患有间质性膀胱炎，证实了这些标准在确定研究的同质性人群方面的研究价值。然而，严格应用NIDDK标准会误诊超过60%的被研究人员认为肯定或可能患有间质性膀胱炎的患者。结论：NIDDK标准对临床医生用作间质性膀胱炎的诊断定义过于严格。
Purpose: The lack of a precise working definition of interstitial cystitis may have resulted in the de facto use of the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) "research" definition by clinicians. We evaluated these strict criteria in light of the broader inclusion criteria for patients evaluated in the Interstitial Cystitis Database study to determine their utility in clinical practice as a useful basis for the diagnosis of interstitial cystitis.Materials and Methods: A total of 379 women who completed screening for the Interstitial Cystitis Database before January 1, 1996 met the basic criteria of urinary frequency, urgency or pain for at least 6 months in duration without a diagnosable etiology. Of these patients 148 underwent cystoscopy and hydrodistention of the bladder as a part of the evaluation. All patients were followed for a minimum of 1 year. Comparisons were made between patients judged to have a clinical diagnosis of interstitial cystitis and those who met the NIDDK research definition of the syndrome.Results: Almost 90% of patients potentially meeting NIDDK criteria are believed by experienced clinicians to have interstitial cystitis, confirming the research value of these criteria in defining a homogeneous population for study. However, strict application of NIDDK criteria would have misdiagnosed more than 60% of patients regarded by researchers as definitely or likely to have interstitial cystitis.Conclusions: The NIDDK criteria are too restrictive to he used by clinicians as the diagnostic definition of interstitial cystitis.