Diet induced obesity increases the risk of colonic tumorigenesis in mice.
Diet induced obesity increases the risk of colonic tumorigenesis in mice.
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饮食引起的肥胖会增加小鼠结肠肿瘤发生的风险。
DOI：
10.1007/s12253-013-9626-0
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Fleming,SharonE
中科院分区：
文献类型：
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作者：
Sikalidis,AngelosK;Fitch,MarkD;Fleming,SharonE
大量流行病学数据表明，肥胖会增加人类患结肠癌的风险。利用啮齿类动物模型研究肥胖和结肠癌之间的关系的研究有限。本研究采用野生型饮食诱导肥胖（DIO）小鼠和瘦野生型对照，研究肥胖对结肠癌风险的影响。我们假设肥胖表型会增加结肠肿瘤的发生。通过给小鼠注射偶氮氧甲烷（AOM），我们通过实验确定了在循环血液中产生等量的AOM浓度，从而化学诱导结肠癌。通过显微镜检查整个结肠的异常隐窝、异常隐窝病灶和增殖水平来评估结肠癌的风险。与野生型对照小鼠相比，DIO小鼠具有明显更多的异常隐窝和异常隐窝病灶，并且每只小鼠的结肠细胞增殖增加，这支持了肥胖增加结肠肿瘤发生风险的流行病学数据。
A large body of epidemiological data indicates that obesity increases the risk of colon cancer in humans. There are limited studies using rodent models where the relationship between obesity and colon cancer has been studied. In this study, wild-type diet-induced obese (DIO) mice and lean wild-type controls were used to investigate the influence of obesity on the risk of colon cancer. We hypothesized that the obese phenotype would exhibit increased colonic tumorigenesis. Colon cancer was chemically induced by injecting the mice with azoxymethane (AOM) at levels that we experimentally determined to result in equivalent AOM concentrations in circulating blood. Risk of colon cancer was assessed via microscopic examination of entire colons for aberrant crypts, aberrant crypt foci and proliferation levels. The DIO mice were found to have significantly more aberrant crypts and aberrant crypt foci as well as increased proliferation of colonocytes per mouse compared to wild-type control mice, supporting the epidemiological data that obesity increases the risk of colonic tumorigenesis.
药物设计中的分子修饰：化学进展系列 45。Robert F. Gould，编辑，美国化学会，华盛顿特区，1964 年，5.00 美元，228 页
DOI：
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发表时间：
1965
期刊：
影响因子：
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作者：
J. Gajewski
通讯作者：
J. Gajewski