The Microbiology of Bloodstream Infection: 20-Year Trends from the SENTRY Antimicrobial Surveillance Program
The Microbiology of Bloodstream Infection: 20-Year Trends from the SENTRY Antimicrobial Surveillance Program
复制标题
DOI：
10.1128/aac.00355-19
复制
发表时间：
2019-07-01
影响因子：
4.9
通讯作者：
Jones, Ronald N.
中科院分区：
文献类型：
--
作者：
Diekema, Daniel J.;Hsueh, Po-Ren;Jones, Ronald N.
在1997年至2016年期间，从45个国家的200多个医疗中心连续收集了血液感染（BSI）微生物。菌种鉴定和药敏试验在中心实验室遵循临床和实验室标准化研究所肉汤微量稀释法。收集了264，901例BSI事件的临床数据和分离株。最常见的病原体是金黄色葡萄球菌（20.7%），其次是大肠埃希菌（20.5%）、肺炎克雷伯菌（7.7%）、铜绿假单胞菌（5.3%）和粪肠球菌（5.2%）。S.金黄色葡萄球菌是1997年至2004年期间最常见的病原体，但E. 2005年以后，柯尔特是最常见的。病原体频率因地理区域、医院发病或社区发病状态和患者年龄而异。S.在所有地区，对苯唑西林耐药的金黄色葡萄球菌分离株（ORSA）在2005年至2008年期间增加，然后在医院发病和社区获得性BSI中下降。万古霉素耐药肠球菌（VRE）的患病率在2012年后保持稳定（总体为16.4%）。S.金黄色葡萄球菌和肠球菌（DRE）仍然罕见（
Bloodstream infection (BSI) organisms were consecutively collected from >200 medical centers in 45 nations between 1997 and 2016. Species identification and susceptibility testing followed Clinical and Laboratory Standards Institute broth microdilution methods at a central laboratory. Clinical data and isolates from 264,901 BSI episodes were collected. The most common pathogen overall was Staphylococcus aureus (20.7%), followed by Escherichia coli (20.5%), Klebsiella pneumoniae (7.7%), Pseudomonas aeruginosa (5.3%), and Enterococcus faecalis (5.2%). S. aureus was the most frequently isolated pathogen overall in the 1997-to-2004 period, but E. colt was the most common after 2005. Pathogen frequency varied by geographic region, hospital-onset or community-onset status, and patient age. The prevalence of S. aureus isolates resistant to oxacillin (ORSA) increased until 2005 to 2008 and then declined among hospital-onset and community-acquired BSI in all regions. The prevalence of vancomycin-resistant enterococci (VRE) was stable after 2012 (16.4% overall). Daptomycin resistance among S. aureus and enterococci (DRE) remained rare (