Molecular diagnostic and surveillance tools for global malaria control.
Molecular diagnostic and surveillance tools for global malaria control.
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DOI：
10.1016/j.tmaid.2007.10.001
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发表时间：
2008-01-01
影响因子：
12
通讯作者：
Kain, Kevin C
中科院分区：
文献类型：
--
作者：
Erdman, Laura K;Kain, Kevin C
疟疾是世界上最具破坏性的寄生虫感染，每年造成100多万人死亡和广泛发病。过去几十年来，疟疾给全球造成的负担有所增加，疟疾输入非流行地区的比率也有所增加。快速和准确的诊断是疟疾控制战略的一个重要组成部分，需要进行流行病学监测，以监测疟疾流行和抗疟药物抗药性的趋势。传统的疟疾诊断和监测工具可能既繁琐又缓慢，而且在灵敏度和特异性方面都有局限性。为了克服这些限制，人们开发了新的分子技术。这些分子技术进行了讨论，就其技术的优点和缺点，重点是在疟疾流行和非流行地区实施的实用性。
Malaria is the most devastating parasitic infection in the world, annually causing over 1 million deaths and extensive morbidity. The global burden of malaria has increased over the last several decades, as have rates of imported malaria into non-endemic regions. Rapid and accurate diagnostics are a crucial component of malaria control strategies, and epidemiological surveillance is required to monitor trends in malaria prevalence and antimalarial drug resistance. Conventional malaria diagnostic and surveillance tools can be cumbersome and slow with limitations in both sensitivity and specificity. New molecular techniques have been developed in an attempt to overcome these restrictions. These molecular techniques are discussed with regard to their technical advantages and disadvantages, with an emphasis on the practicality of implementation in malaria-endemic and non-endemic regions.