Oscillatory Entrainment of Primary Somatosensory Cortex Encodes Visual Control of Tactile Processing
Oscillatory Entrainment of Primary Somatosensory Cortex Encodes Visual Control of Tactile Processing
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DOI：
10.1523/jneurosci.4432-12.2013
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发表时间：
2013-03
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影响因子：
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通讯作者：
Kay Sieben;B. Röder;I. Hanganu-Opatz
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作者：
Kay Sieben;B. Röder;I. Hanganu-Opatz
最佳行为依赖于多种感官互补信息的成功整合。多感官相互作用背后的神经机制仍然知之甚少。在这里，我们展示了神经网络振荡和初级感觉皮层之间的直接连接在视觉体感相互作用中的关键作用。布朗挪威大鼠体内桶状场各层的细胞外记录表明，双模式刺激（同时闪光和胡须偏转）增强了体感诱发反应，并通过重置相位来改变诱导网络振荡的功率。解剖追踪揭示了初级视觉（V1）和体感（S1）皮层之间稀疏的直接连接。 V1 的药理学沉默减弱但并未消除对 S1 振荡活动的跨模式影响，同时使诱发反应的早期增强不受影响。因此，视觉刺激似乎通过皮质投射和皮质下前馈相互作用调节 S1 中的网络振荡来影响触觉处理。
Optimal behavior relies on the successful integration of complementary information from multiple senses. The neural mechanisms underlying multisensory interactions are still poorly understood. Here, we demonstrate the critical role of neural network oscillations and direct connectivity between primary sensory cortices in visual-somatosensory interactions. Extracellular recordings from all layers of the barrel field in Brown Norway rats in vivo showed that bimodal stimulation (simultaneous light flash and whisker deflection) augmented the somatosensory-evoked response and changed the power of induced network oscillations by resetting their phase. Anatomical tracing revealed sparse direct connectivity between primary visual (V1) and somatosensory (S1) cortices. Pharmacological silencing of V1 diminished but did not abolish cross-modal effects on S1 oscillatory activity, while leaving the early enhancement of the evoked response unaffected. Thus, visual stimuli seem to impact tactile processing by modulating network oscillations in S1 via corticocortical projections and subcortical feedforward interactions.