Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements using (15)O-water PET.
Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements using (15)O-water PET.
复制标题
使用（15）O-水PET进行定量RCBF测量的健康未培养新生婴儿的混合PET/MRI成像。
DOI：
10.1177/0271678x17751835
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发表时间：
2019-05
期刊：
影响因子：
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通讯作者：
Law I
中科院分区：
文献类型：
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作者：
Andersen JB;Lindberg U;Olesen OV;Benoit D;Ladefoged CN;Larsson HB;Højgaard L;Greisen G;Law I
在这项研究中，评估了一种新的PET/MRI混合方法用于定量测量健康新生儿的区域脑血流（rCBF），并测试了先前通过动脉自旋标记（ASL）获得的白质低rCBF值。4名健康足月新生儿在自然睡眠期间，经中位静脉注射14mbq15o水后，在PET/MRI扫描仪上进行扫描。区域CBF采用左心室图像衍生输入函数（IDIF）的单组织室模型进行量化。PET rCBF值在丘脑、中脑和脑干最高，皮层和无髓鞘白质最低。全球平均CBF为17.8 ml/100 g/min。额部和枕部无髓白质CBF平均为10.3 ml/100 g/min，丘脑CBF平均为31.3 ml/100 g/min。平均脑白质/丘脑比CBF为0.36，显著高于既往ASL数据。rCBF ASL测量都不成功，主要是由于受试者的运动。在这项研究中，我们首次展示了一种微创PET/MRI方法，使用低活性15o -水PET对未镇静的健康新生儿进行定量rCBF评估，并发现白质/灰质CBF比率与成人大脑相似。
In this study, a new hybrid PET/MRI method for quantitative regional cerebral blood flow (rCBF) measurements in healthy newborn infants was assessed and the low values of rCBF in white matter previously obtained by arterial spin labeling (ASL) were tested. Four healthy full-term newborn subjects were scanned in a PET/MRI scanner during natural sleep after median intravenous injection of 14 MBq 15O-water. Regional CBF was quantified using a one-tissue-compartment model employing an image-derived input function (IDIF) from the left ventricle. PET rCBF showed the highest values in the thalami, mesencephalon and brain stem and the lowest in cortex and unmyelinated white matter. The average global CBF was 17.8 ml/100 g/min. The average frontal and occipital unmyelinated white matter CBF was 10.3 ml/100 g/min and average thalamic CBF 31.3 ml/100 g/min. The average white matter/thalamic ratio CBF was 0.36, significantly higher than previous ASL data. The rCBF ASL measurements were all unsuccessful primarily owing to subject movement. In this study, we demonstrated for the first time, a minimally invasive PET/MRI method using low activity 15O-water PET for quantitative rCBF assessment in unsedated healthy newborn infants and found a white/grey matter CBF ratio similar to that of the adult human brain.