Microalbuminuria is more frequent in South Asian than in European origin populations: a comparative study in Newcastle, UK
Microalbuminuria is more frequent in South Asian than in European origin populations: a comparative study in Newcastle, UK
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DOI：
10.1046/j.1464-5491.2003.00822.x
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发表时间：
2003-01-01
影响因子：
3.5
通讯作者：
Alberti, KGMM
中科院分区：
文献类型：
--
作者：
Fischbacher, CM;Bhopal, R;Alberti, KGMM
目的：我们旨在比较英国、南亚人和欧洲人的尿白蛋白排泄水平和微量白蛋白尿的患病率。微量白蛋白尿可预测欧洲血统人群的心血管疾病，但缺乏来自南亚人群的证据。冠状动脉心脏病（CHD）死亡率是40-50%高，在英国南亚人相比，整个population.Methods的原因是不完全了解微量白蛋白尿测定白蛋白肌酐比在年龄和性别分层随机抽样的1509名成年人从欧洲（n = 825），印度（n = 259），结果南亚人尿白蛋白排泄水平显著高于欧洲人（尿白蛋白/肌酐比值的几何平均值为0.83（0.75，0.91））（0.55（0.51，0.60））。微量白蛋白尿与年龄较大，高血压和糖尿病，但独立于这些危险因素尿白蛋白排泄率较高，在南亚人比European.Conclusions尿白蛋白排泄率较高，微量白蛋白尿更频繁，在英国南亚人相比，大多数种族的人口。微量白蛋白尿可能与导致英国南亚人心血管死亡率过高和可能的肾衰竭的因果途径有关。
Aims We aimed to compare levels of urinary albumin excretion and the prevalence of microalbuminuria in UK South Asians and Europeans. Microalbuminuria predicts cardiovascular disease in European origin populations, but evidence from the general population of South Asians is lacking. Coronary heart disease (CHD) mortality is 40-50% higher in UK South Asians compared with the whole population, for reasons that are incompletely understood.Methods Microalbuminuria was measured using the albumin-creatinine ratio in an age- and sex-stratified random sample of 1509 adults from European (n = 825), Indian (n = 259), Pakistani (n = 305) and Bangladeshi (n = 120) ethnic groups.Results Levels of urinary albumin excretion were substantially higher in South Asians (geometric mean albumin creatinine ratio (95% confidence interval) 0.83 (0.75, 0.91)) than in Europeans (0.55 (0.51, 0.60)). Microalbuminuria was associated with older age, hypertension and diabetes, but independently of these risk factors urinary albumin excretion was higher in South Asians than Europeans.Conclusions Urinary albumin excretion is higher and microalbuminuria more frequent in UK South Asians compared with the majority ethnic population. Microalbuminuria may be relevant to the causal pathways leading to the excess of cardiovascular mortality and possibly renal failure in UK South Asians.