Targeting Platelets for the Treatment of Cancer.
Targeting Platelets for the Treatment of Cancer.
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DOI：
10.3390/cancers9070094
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发表时间：
2017-07-22
期刊：
影响因子：
5.2
通讯作者：
Metharom P
中科院分区：
文献类型：
--
作者：
Elaskalani O;Berndt MC;Falasca M;Metharom P
大多数与癌症相关的死亡率是由于肿瘤细胞转移的能力导致多功能器官衰竭和死亡。血液循环中的播散性肿瘤细胞面临着重大挑战，如流变剪切应力和自然杀伤细胞介导的细胞介导的细胞毒性。然而，具有转移能力的循环肿瘤细胞似乎有能力利用宿主细胞来帮助它们存活。尽管长期以来人们对靶向肿瘤相关宿主细胞（如血小板）用于癌症治疗感兴趣，但这种策略的临床益处仍受到质疑。在这篇综述中，我们提供了一个最新的机制和临床证据的总结，以评估在癌症中靶向血小板的有效性。
The majority of cancer-associated mortality results from the ability of tumour cells to metastasise leading to multifunctional organ failure and death. Disseminated tumour cells in the blood circulation are faced with major challenges such as rheological shear stresses and cell-mediated cytotoxicity mediated by natural killer cells. Nevertheless, circulating tumour cells with metastatic ability appear equipped to exploit host cells to aid their survival. Despite the long interest in targeting tumour-associated host cells such as platelets for cancer treatment, the clinical benefit of this strategy is still under question. In this review, we provide a summary of the latest mechanistic and clinical evidence to evaluate the validity of targeting platelets in cancer.
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影响因子：
168.9
作者：
Burn, John;Gerdes, Anne-Marie;Macrae, Finlay;Mecklin, Jukka-Pekka;Moeslein, Gabriela;Olschwang, Sylviane;Eccles, Diane;Evans, D. Gareth;Maher, Eamonn R.;Bertario, Lucio;Bisgaard, Marie-Luise;Dunlop, Malcolm G.;Ho, Judy W. C.;Hodgson, Shirley V.;Lindblom, Annika;Lubinski, Jan;Morrison, Patrick J.;Murday, Victoria;Ramesar, Raj;Side, Lucy;Scott, Rodney J.;Thomas, Huw J. W.;Vasen, Hans F.;Barker, Gail;Crawford, Gillian;Elliott, Faye;Movahedi, Mohammad;Pylvanainen, Kirsi;Wijnen, Juul T.;Fodde, Riccardo;Lynch, Henry T.;Mathers, John C.;Bishop, D. Timothy
通讯作者：
Bishop, D. Timothy
影响因子：
20.3
作者：
Battinelli, Elisabeth M.;Markens, Beth A.;Italiano, Joseph E., Jr.
通讯作者：
Italiano, Joseph E., Jr.
影响因子：
4.8
作者：
Benesch, Matthew G. K.;Tang, Xiaoyun;Brindley, David N.
通讯作者：
Brindley, David N.
影响因子：
4.4
作者：
Caine, GJ;Lip, GY;Blann, AD
通讯作者：
Blann, AD
影响因子：
3.6
作者：
Alexander, Eric T.;Minton, Allyson R.;Gilmour, Susan K.
通讯作者：
Gilmour, Susan K.