Development of the anterior visual input pathway to the Drosophila central complex.
Development of the anterior visual input pathway to the Drosophila central complex.
复制标题
果蝇中央复合体的前视觉输入通路的发育。
DOI：
10.1002/cne.24277
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Hartenstein,Volker
中科院分区：
文献类型：
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作者：
Lovick,JenniferK;Omoto,JaisonJ;Ngo,KathyT;Hartenstein,Volker
前视觉通路（AVP）将视觉信息从视叶髓质经前视结节（AOTU）和球（BU）传导至中央复合体的椭圆体（EB）。连接AOTU、BU和EB的解剖学上定义的神经元类别代表离散谱系，遗传和发育上指定的源自共同祖细胞的细胞集（Omoto et al.，Current Biology，27，1098-1110，2017）。本文分析了从早期幼虫到成虫阶段AVP的形成过程。AVP的未成熟纤维束由谱系DALc 1/2和DALv 2的次级神经元形成，组装成晚期幼虫脑内的AOTU、BU和EB的结构不同的原基。在早期蛹期（P6-P48），这些原基的大小增长，并分化成AOTU，BU和EB的最终亚室。EB的原基具有复杂的组成。DALv 2神经元形成前EB原基，其开始为双侧结构，然后穿过P6和P12之间的中线，随后弯曲以采用成熟EB的环形。由II型谱系DM 1 - 4产生的中央复合体的柱状神经元形成后EB原基。作为扇形体原基的一个组成部分，后EB原基向前移动并与前EB原基合并。我们记录了新生EB和BU周围的神经胶质细胞的延伸，并分析了AVP谱系的初级和次级神经元的关系。
The anterior visual pathway (AVP) conducts visual information from the medulla of the optic lobe via the anterior optic tubercle (AOTU) and bulb (BU) to the ellipsoid body (EB) of the central complex. The anatomically defined neuron classes connecting the AOTU, BU, and EB represent discrete lineages, genetically and developmentally specified sets of cells derived from common progenitors (Omoto et al., Current Biology, 27, 1098–1110, 2017). In this article, we have analyzed the formation of the AVP from early larval to adult stages. The immature fiber tracts of the AVP, formed by secondary neurons of lineages DALcl1/2 and DALv2, assemble into structurally distinct primordia of the AOTU, BU, and EB within the late larval brain. During the early pupal period (P6–P48) these primordia grow in size and differentiate into the definitive subcompartments of the AOTU, BU, and EB. The primordium of the EB has a complex composition. DALv2 neurons form the anterior EB primordium, which starts out as a bilateral structure, then crosses the midline between P6 and P12, and subsequently bends to adopt the ring shape of the mature EB. Columnar neurons of the central complex, generated by the type II lineages DM1‐4, form the posterior EB primordium. Starting out as an integral part of the fan‐shaped body primordium, the posterior EB primordium moves forward and merges with the anterior EB primordium. We document the extension of neuropil glia around the nascent EB and BU, and analyze the relationship of primary and secondary neurons of the AVP lineages.