Low pulmonary function is related with a high risk of sarcopenia in community-dwelling older adults: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2011
Low pulmonary function is related with a high risk of sarcopenia in community-dwelling older adults: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2011
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DOI：
10.1007/s00198-015-3152-8
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发表时间：
2015-10-01
影响因子：
4
通讯作者：
Kim, I. J.
中科院分区：
文献类型：
--
作者：
Jeon, Y. K.;Shin, M. J.;Kim, I. J.
总结 肌肉减少症是老年人中与年龄相关的骨骼肌质量减少。呼吸肌力量可能与骨骼肌质量有关，因此，本研究试图估计与肺功能下降相关的肌少症风险。目前的研究结果表明，社区老年人的低肺功能与低肌肉质量有关。 简介 瘦体重与慢性阻塞性肺病 (COPD) 患者的肺功能有关。然而，健康老年人的肌肉质量和肺功能之间的关系尚未明确。因此，本研究调查了居住在社区的韩国老年人群中肺功能与肌肉质量的关系。 方法 本研究纳入了 463 名 65 岁以上的无病受试者，他们在 2008-2011 年韩国国家健康和营养检查调查 (KNHANES) 中接受了人体测量、实验室测试、肺活量测定和四肢骨骼肌 (ASM) 质量估计。低肌肉质量定义为 ASM 值除以身高平方 (ASM/身高 (2))，该值比年轻参照组的性别特定平均值低两个标准差 (SD)。结果 1 秒用力呼气量 (FEV1[L]) 和用力肺活量 (FVC[L]) 与男性中的 ASM/身高 (2) 呈正相关（p < 0.001 和 p = 0.001，分别），但在女性中则不然（分别为 p = 0.360 和 p = 0.779）。单变量逻辑回归分析显示，FEV1 或 FVC 较低的男性更有可能肌肉质量较低（FEV1 的比值比 [OR] = 3.11，95% 置信区间 [CI] 1.62-5.99；FVC 的 OR = 1.99，95% CI 1.13-3.53）；女性也发现了类似的结果，但显着性较低（对于 FEV1，OR = 11.37，95% CI 0.97-132.91；对于 FVC，OR = 7.31，95% CI 1.25-42.74）。调整年龄、吸烟和中等体力活动后，低 FEV1 值与男性（OR = 2.90，95 % CI 1.50-5.63）和女性（OR = 9.15，95 % CI 1.53-54.77）的低肌肉质量相关。 结论 使用 2008-2011 KNHANES 的全国代表性数据，发现低肺功能与低肌肉质量相关。居住在社区的韩国老年人肌肉质量较低。
The Summary Sarcopenia is the age-related reduction of skeletal muscle mass in older individuals. Respiratory muscle strength may be related to skeletal muscle mass and, thus, the present study attempted to estimate the risk of sarcopenia relative to decreased pulmonary function. The present findings demonstrated that low pulmonary function was associated with low muscle mass in community-dwelling older adults.Introduction Lean body mass is related to pulmonary function in patients with chronic obstructive pulmonary disease (COPD). However, the relationship between muscle mass and pulmonary function in healthy older adults has yet to be clarified. Thus, the present study investigated the association of pulmonary function with muscle mass in an older community-dwelling Korean population.Methods This study included 463 disease-free subjects over 65 years of age who underwent anthropometric measurements, laboratory tests, spirometry, and the estimation of appendicular skeletal muscle (ASM) mass in the 2008-2011 Korea National Health and Nutrition Examination Survey (KNHANES). Low muscle mass was defined as the value of ASM divided by height squared (ASM/height(2)) that was less than two standard deviations (SD) below the sex-specific mean of the young reference group.Results Forced expiratory volume in 1 s (FEV1[L]) and forced vital capacity (FVC[L]) were positively correlated with ASM/height(2) in males (p < 0.001 and p = 0.001, respectively) but not in females (p = 0.360 and p = 0.779, respectively). A univariate logistic regression analysis revealed that males with low FEV1 or FVC were more likely to have low muscle mass (odds ratio [OR] = 3.11, 95 % confidence interval [CI] 1.62-5.99 for FEV1; OR = 1.99, 95 % CI 1.13-3.53 for FVC); similar results were found for females, but the significance was lower (OR = 11.37, 95 % CI 0.97-132.91 for FEV1; OR = 7.31, 95 % CI 1.25-42.74 for FVC). After adjusting for age, smoking, and moderate physical activity, a low FEV1 value was associated with low muscle mass in both males (OR = 2.90, 95 % CI 1.50-5.63) and females (OR = 9.15, 95 % CI 1.53-54.77).Conclusion Using nationally representative data from the 2008-2011 KNHANES, low pulmonary function was found to be associated with low muscle mass in community-dwelling older Korean adults.