Frailty, health-related quality of life and mental well-being in older adults with cardiometabolic risk factors
Frailty, health-related quality of life and mental well-being in older adults with cardiometabolic risk factors
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DOI：
10.1111/j.1742-1241.2008.01830.x
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发表时间：
2008-09-01
影响因子：
2.6
通讯作者：
Saito, Y.
中科院分区：
文献类型：
--
作者：
Kanauchi, M.;Kubo, A.;Saito, Y.
目的：虚弱是老年人的一种突发性健康问题。本研究的目的是探讨健康相关的生活质量（HRQOL）和虚弱的影响，在老年患者的心脏代谢危险因素。研究方法：101例65岁或以上的患者使用世界卫生组织生活质量（WHOQOL）-26问卷进行了HRQOL评估。脆弱性评估使用两个指数：希伯来老年人康复中心（HRCA）脆弱性指数和脆弱老年人调查（VES）指数。此外，这些患者还完成了评估心理健康[一般健康问卷（GHQ-28）的28项版本]和抑郁症（老年抑郁量表）的自评问卷。结果：根据HRCA和VES指标，24例（23.7%）符合虚弱标准。年龄≥ 75岁、有抑郁情绪或肌酐清除率较低的患者WHOQOL-26评分显著低于其对应人群。糖尿病和大血管并发症与WHOQOL-26评分无关。与非虚弱患者相比，在调整了年龄、肾功能不全和抑郁情绪后，虚弱患者的WHOQOL-26问卷得分较低。与非虚弱患者相比，虚弱患者还报告了显著更高的GHQ-28评分。结论：虚弱的老年人有一个显着较低的HRQOL，以及较低的心理健康，独立于年龄，糖尿病，大血管并发症，肾功能不全和抑郁情绪。
Objective: Frailty is an emergent health-related problem in older adults. The aim of this study was to examine the health-related quality of life (HRQOL) and the effect of frailty in elderly patients with cardiometabolic risk factors. Methods: One-hundred and one patients 65 years or older responded to an HRQOL assessment using the World Health Organization Quality of Life (WHOQOL)-26 questionnaire. Frailty was assessed using two indices: the Hebrew Rehabilitation Center for Aged (HRCA) vulnerability index and the Vulnerable Elders Survey (VES) index. In addition, these patients completed self-rating questionnaires assessing mental well-being [the 28-item version of the General Health Questionnaire (GHQ-28)] and depression (Geriatric Depression Scale). Results: Based on the combination of HRCA and VES indices, 24 subjects (23.7%) met the criteria of frail. Persons >= 75 years old and those with depressive mood or lower creatinine clearance had significantly lower WHOQOL-26 scores than their counterparts. Diabetes and macrovascular complications did not associate with the WHOQOL-26 scores. Compared with non-frail patients, the frail scored lower on the WHOQOL-26 questionnaire after adjusting for age, kidney dysfunction and depressive mood. Frail patients also reported significantly higher the GHQ-28 scores compared with non-frail patients. Conclusions: Frail older adults had a significant lower HRQOL, as well as lower mental well-being, independent of age, diabetes, macrovascular complication, kidney dysfunction and depressed mood.