Integrated databanks access and sequence/structure analysis services at the PBIL

Integrated databanks access and sequence/structure analysis services at the PBIL
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DOI:
10.1093/nar/gkg530
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发表时间:
2003-07-01
影响因子:
14.9
通讯作者:
Deléage, G
Deléage, G
中科院分区:
生物学2区
文献类型:
--
作者:
Perrière, G;Combet, C;Deléage, G

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PBIL(Pole Bioinformatique Lyonnais)的万维网服务器提供对序列数据库以及许多核酸和蛋白质序列分析工具的在线访问。该服务器允许查询 EMBL 和 GenBank 格式的核苷酸序列库以及 SWISS-PROT 和 PIR 格式的蛋白质序列库。我们的数据库访问所基于的查询引擎是ACNUC系统。它允许构建复杂的查询来访问生物感兴趣的功能区并检索大型序列集。特别令人感兴趣的是该系统提供的独特功能,用于查询 PBIL 开发的基因家族数据库。该服务器还提供对各种序列分析方法的访问:相似性搜索程序、多重比对、蛋白质结构预测和多元统计。该服务器的独创性在于集成了序列检索和序列分析这两个方面。事实上,由于可重用列表的引入,可以对大量数据进行处理。可以通过以下网址访问 PBIL 服务器:http://pbil.univ-lyon1.fr。
The World Wide Web server of the PBIL (Pole Bioinformatique Lyonnais) provides on-line access to sequence databanks and to many tools of nucleic acid and protein sequence analyses. This server allows to query nucleotide sequence banks in the EMBL and GenBank formats and protein sequence banks in the SWISS-PROT and PIR formats. The query engine on which our data bank access is based is the ACNUC system. It allows the possibility to build complex queries to access functional zones of biological interest and to retrieve large sequence sets. Of special interest are the unique features provided by this system to query the data banks of gene families developed at the PBIL. The server also provides access to a wide range of sequence analysis methods: similarity search programs, multiple alignments, protein structure prediction and multivariate statistics. An originality of this server is the integration of these two aspects: sequence retrieval and sequence analysis. Indeed, thanks to the introduction of re-usable lists, it is possible to perform treatments on large sets of data. The PBIL server can be reached at: http://pbil.univ-lyon1.fr.