Inflammation, infection, and aortic valve sclerosis - Insights from the Olmsted County (Minnesota) population
Inflammation, infection, and aortic valve sclerosis - Insights from the Olmsted County (Minnesota) population
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DOI：
10.1016/j.atherosclerosis.2004.01.028
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发表时间：
2004-06-01
期刊：
影响因子：
5.3
通讯作者：
Meissner, I
中科院分区：
文献类型：
--
作者：
Agmon, Y;Khandheria, BK;Meissner, I
动脉粥样硬化相关机制，包括炎症和可能的感染，可能参与钙化主动脉瓣疾病的发病机制。本研究的目的是研究在普通人群样本中，系统性炎症标志物和肺炎衣原体血清阳性是否与主动脉瓣硬化（AVS）相关。经食管超声心动图对381名受试者（中位年龄：67岁，范围：51-101岁；52%为男性）进行了检查，这些受试者来自明尼苏达州奥姆斯特德县的成年人群。检查全身炎症标志物（血细胞计数，包括白细胞差异计数、纤维蛋白原和高敏c反应蛋白[hs-CRP]）、肺炎梭菌免疫球蛋白G （IgG）抗体滴度和AVS之间的关系。140名受试者（占总人数的37%）出现AVS。调整年龄、性别和吸烟状况后：(1)hs-CRP与AVS相关（比值比：1.20 / hs-CRP升高两倍；95%可信区间：1.01-1.43;P = 0.04），但在调整了AVS的其他危险因素，包括体重指数后，这种关联不显著（P = 0.52）。(2)血球计数和纤维蛋白原与AVS无相关性（p值>0.30）。(3)肺炎原体IgG抗体滴度（低滴度[1:16-1:32]、中滴度[1:64-1:128]、高滴度[大于等于1:256]）与滴度比较
Atherosclerosis-related mechanisms, including inflammation and possibly infection, are likely to be involved in the pathogenesis of calcitic aortic valve disease. The purpose of this study was to examine whether systemic inflammatory markers and Chlamydia pneumoniae seropositivity are associated with aortic valve sclerosis (AVS) in a sample of the general population. Transesophageal echocardiography was performed in 381 subjects (median age: 67 years, range: 51-101; 52% men), a sample of the adult population in Olmsted County, Minnesota. The associations between systemic inflammatory markers (blood counts, including white blood cells differential counts, fibrinogen, and high-sensitivity C-reactive protein [hs-CRP]), C. pneumoniae immunoglobulin G (IgG) antibody titers, and AVS were examined. AVS was present in 140 subjects (37% of the population). After adjustment for age, sex, and smoking status: (1) hs-CRP was associated with AVS (odds ratio: 1.20 per two-fold increase in hs-CRP; 95% confidence interval: 1.01-1.43; P = 0.04), but this association was not significant after adjustment for additional risk factors for AVS, including body mass index (P = 0.52). (2) Blood counts and fibrinogen were not associated with AVS (P-values >0.30).(3) C. pneumoniae IgG antibody titers (low [1:16-1:32], intermediate [1:64-1:128], or high [greater than or equal to1:256] titers, compared with titers