The mechanism of alloxan protection in experimental atherosclerosis.
The mechanism of alloxan protection in experimental atherosclerosis.
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DOI：
10.1084/jem.99.2.119
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发表时间：
1954-02
期刊：
影响因子：
--
通讯作者：
GREEN DM
中科院分区：
文献类型：
--
作者：
COOK DL;MILLS LM;GREEN DM
实验比较了(a)对照兔、(b)四氧嘧啶糖尿病兔和(c)胰腺暂时阻断循环注射四氧嘧啶兔的胆固醇饲喂效果。四氧嘧啶糖尿病家兔摄入大量胆固醇和食物，血清胆固醇和脂蛋白（Sf - 5-9和Sf - 16-30）浓度显著高于对照水平。他们没有显示出动脉粥样硬化程度的相应增加。在给药期间，通过暂时阻断胰腺循环来阻止四氧嘧啶致糖尿病作用的家兔出现了高胆固醇血症、高脂蛋白血症和动脉粥样硬化的等级，与对照组没有显著差异。该结果被解释为表明四氧嘧啶对胰腺以外组织的作用不能防止由胆固醇喂养引起的实验性动脉粥样硬化。
Experiments were performed to compare the effects of cholesterol feeding in (a) control rabbits, (b) alloxan-diabetic rabbits, and (c) rabbits injected with alloxan while the pancreas was temporarily occluded from the circulation. The alloxan-diabetic rabbits consumed significantly higher quantities of cholesterol and food and had serum cholesterol and lipoprotein (Sf 5–9 and Sf 16–30) concentrations significantly increased over the control levels. They failed to show a commensurate increase in the degree of atherosclerosis. Rabbits in which the diabetogenic action of alloxan was prevented by temporary occlusion of the pancreas from the circulation during its administration developed grades of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis not significantly different from the controls. The results are interpreted as indicating that the effects of alloxan on tissues other than the pancreas do not protect against experimental atherosclerosis produced by cholesterol feeding.