Comparison of early recovery and cognitive function after desflurane and sevoflurane anaesthesia in elderly patients: A meta-analysis of randomized controlled trials
Comparison of early recovery and cognitive function after desflurane and sevoflurane anaesthesia in elderly patients: A meta-analysis of randomized controlled trials
复制标题
老年患者地氟烷和七氟烷麻醉后早期恢复和认知功能的比较：随机对照试验的荟萃分析
DOI：
10.1177/0300060515591064
复制
发表时间：
2015-10-01
影响因子：
1.6
通讯作者：
Zhou, Haiyan
中科院分区：
文献类型：
--
作者：
Chen, Gang;Zhou, Youfa;Zhou, Haiyan
目的通过荟萃分析，比较七氟醚和地氟醚麻醉的老年患者（年龄0 ~ 65岁）术后认知功能和特定恢复事件的时间。方法以“七氟醚”和“地氟醚”为关键词，系统检索PubMed (R)、Embase (R)、Cochrane Library和Chinese Biomedical database。提取适当的随机对照试验（RCTs）的数据和特征。结果meta分析包括5项试验（n=300）。地氟醚组患者的指令执行时间（平均差值[MD] -3.27； 95%可信区间[CI] -4.95, -1.59）、拔管时间（MD -1.59; 95%CI -2.62, -0.55）、定向时间（MD -4.31; 95%CI -4.99, -3.62）和出院时间（MD -9.38; 95%CI -13.43, -5.42）均显著短于七氟醚组。两种药物在术后认知功能障碍发生率和睁眼时间上无显著差异。结论老年患者全身麻醉后地氟醚比七氟醚恢复更快。
ObjectivesA meta-analysis to compare postoperative cognitive function and the time to specific recovery events in elderly patients (aged >65 years) anaesthetized with sevoflurane or desflurane. MethodsA systematic search of the PubMed (R), Embase (R), Cochrane Library and Chinese Biomedical databases was performed using the keywords sevoflurane' and desflurane'. Data and characteristics of appropriate randomized controlled trials (RCTs) were extracted. ResultsThe meta-analysis included five trials (n=300). The time taken to follow commands (mean difference [MD] -3.27; 95% confidence intervals [CI] -4.95, -1.59), extubation (MD -1.59; 95%CI -2.62, -0.55), orientation (MD -4.31; 95%CI -4.99, -3.62), and recovery room discharge (MD -9.38; 95%CI -13.43, -5.42) were significantly shorter in the desflurane group than in the sevoflurane group. There was no significant between-drug difference in the incidence of postoperative cognitive dysfunction or the time taken to open the eyes. ConclusionsDesflurane is associated with a faster recovery from general anaesthesia than sevoflurane in elderly patients.