Circulating chemerin levels elevated in dilated cardiomyopathy patients with overt heart failure
Circulating chemerin levels elevated in dilated cardiomyopathy patients with overt heart failure
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伴有明显心力衰竭的扩张型心肌病患者循环凯莫瑞水平升高
DOI：
10.1016/j.cca.2015.05.018
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发表时间：
2015-08-25
影响因子：
5
通讯作者：
Zhou, Yu-Jie
中科院分区：
文献类型：
--
作者：
Zhang, Ou;Ji, Qingwei;Zhou, Yu-Jie
工作背景：最近的证据表明，循环中脂肪因子的浓度与缺血性心脏病和扩张型心肌病（DCM）继发性心力衰竭的存在有关。然而，在DCM患者的chemerin的血浆浓度还有待investigated.Methods：本研究纳入了109例DCM患者的典型症状的心力衰竭和60名健康对照组和测定chemerin，IL-6和TNF-α的血浆浓度使用酶联免疫吸附试验。结果：DCM患者血浆chemerin、IL-6和TNF-α浓度均显著高于对照组，差异有统计学意义（P < 0. 05）。相关分析显示，血浆chemerin浓度与IL-6浓度呈正相关（R = 0.270，P = 0.004），TNF-α（R = 0.302，P = 0.001）、C反应蛋白（CRP）（R = 0.256，P = 0.004），N末端脑钠肽前体NT-proBNP（R = 0386，P = 0.000）、LVEDD（R = 0212，P = 0.027）与LVEF呈负相关（R = 0.543，P = 0.000）。此外，在多变量回归模型中加入NT-proBNP之前，chemerin（OR 1.102，95%CI 1.052 - 1.153; p = 0.000）与DCM的存在独立相关。(C)2015 Elsevier B. V.版权所有。
Background: Recent evidence demonstrated that the circulating concentrations of adipokine are related to the presence of heart failure secondary to ischemic heart disease and dilated cardiomyopathy (DCM). However, the plasma concentrations of chemerin in patients with DCM have yet to be investigated.Methods: The present study enrolled 109 DCM patients with typical symptoms of heart failure and 60 healthy controls and measured plasma concentrations of chemerin, IL-6 and TNF-alpha using enzyme-linked immunosorbent assay. Left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were measured using a GE ViVid E7 ultrasonography machine.Results: Plasma chemerin, IL-6 and TNF-alpha concentrations were significantly higher in DCM patients compared to the control group. A correlation analysis revealed that plasma chemerin concentrations were positively correlated with the concentrations of IL-6 (R = 0.270, P = 0.004), TNF-alpha (R = 0.302, P = 0.001), C-reactive protein (CRP) (R = 0.256, P = 0.004), N-terminal pro-brain natriuretic peptide (NT-proBNP) (R = 0386, P = 0.000), and LVEDD (R = 0212, P = 0.027) but negatively correlated with LVEF (R = 0.543, P = 0.000). Furthermore, chemerin (OR 1.102,95% CI 1.052 to 1.153; p = 0.000) was independently associated with the presence of DCM before NT-proBNP was added in the multivariable regression model.Conclusions: The results indicate that chemerin is a novel biomarker of DCM. (C) 2015 Elsevier B.V. All rights reserved.