Association between declines in objective masticatory performance and salivary stress markers: the Suita study.
Association between declines in objective masticatory performance and salivary stress markers: the Suita study.
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客观咀嚼性能下降与唾液压力标记物之间的关联：吹田研究。
DOI：
10.1111/joor.13146
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发表时间：
2021
影响因子：
2.9
通讯作者：
Kazunori Ikebe
中科院分区：
文献类型：
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作者：
Takayuki Kosaka;Takahiro Ono;Momoyo Kida;Shuri Fushida;Takashi Nokubi;Yoshihiro Kokubo;Makoto Watanabe;Aya Higashiyama;Yoshihiro Miyamoto;Kazunori Ikebe
牙医经常遇到由于咀嚼性能下降而遭受心理和社会压力的患者，这使这成为一个需要处理的关键问题。我们的目的是阐明唾液应激标志物作为慢性应激的客观指标与一般日本城市人群的客观咀嚼表现之间的关系。使用了Suita研究中880名参与者(平均年龄为65.8岁)的数据。采用酶联免疫吸附试验检测唾液中白细胞介素6(IL-6)和皮质醇的浓度。目的通过测量咀嚼30次后测试胶冻的表面积增加来确定咀嚼性能。参与者根据咀嚼性能被分为两组：减少组(最低四分位数)和非减少组(第二到第四四分位数)。采用Logistic回归分析对年龄、性别、牙周状况、唾液流率和吸烟习惯进行校正，估计唾液压力标记物水平较高(最高四分位数)与咀嚼能力的优势比(OR)。唾液IL-6水平下降组明显高于非下降组。Logistic回归分析显示，唾液IL-6水平降低组的调整OR显著高于未降低组(OR=91.92；95%可信区间=1.33~2.76；P<；等.001)。在任何分析中，没有发现唾液皮质醇和咀嚼性能下降之间的显著关联。客观咀嚼能力的下降可能与唾液IL-6水平升高有关，作为慢性应激的客观指标。
Dentists often encounter patients suffering from psychological and social stress due to declines in masticatory performance, making this a critical issue to manage. We aimed to clarify the relationships between salivary stress markers as objective indices of chronic stress and objective masticatory performance in a general urban Japanese population. Data from 880 participants (mean age, 65.8 years) in the Suita study were used. Salivary interleukin (IL)‐6 and cortisol concentrations were measured by enzyme‐linked immunosorbent assay. Objective masticatory performance was determined by measuring the increase in surface area test gummy jelly after 30 times chewing. Participants were divided into two groups based on masticatory performance: a decreased group (lowest quartile) and a non‐decreased group (second to fourth quartiles). Odds ratios (ORs) of higher salivary levels of stress markers (highest quartile) according to masticatory performance were estimated using logistic regression analysis adjusting for age, sex, periodontal status, salivary flow rate and smoking habit. Salivary IL‐6 level was significantly higher in the decreased group than in the non‐decreased group. Logistic regression analysis showed the adjusted OR for higher salivary IL‐6 was significantly higher in the decreased group than in the non‐decreased group (OR = 1.92; 95% confidence interval = 1.33‐2.76;P< .001). No significant associations were found between salivary cortisol and decreased masticatory performance in any analyses. Declines in objective masticatory performance may correlate with higher salivary IL‐6 level as an objective index of chronic stress.
老年全口义齿佩戴者口腔立体能力与咀嚼性能之间的关联
DOI：
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发表时间：
--
期刊：
The International journal of prosthodontics in press
影响因子：
--
作者：
Shiokawa D.;Tanuma S.;Sasamoto M;Ikebe K
通讯作者：
Ikebe K