Parameters of Left Ventricular Mass and Dementia: Moving the Literature Forward.
Parameters of Left Ventricular Mass and Dementia: Moving the Literature Forward.
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左心室质量参数和痴呆：推动文献向前发展。
DOI：
10.1161/hypertensionaha.117.10371
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Davey,Adam
中科院分区：
文献类型：
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作者：
Elias,MerrillF;Torres,RachaelV;Davey,Adam
迄今为止，所有研究的一个更广泛的局限性是关注全因痴呆，而不是单独评估阿尔茨海默病，血管性痴呆和混合性痴呆。这些研究对于确定心血管疾病（包括LV肥大）在从正常认知功能进展为痴呆中所起的特定作用非常重要。这个问题很重要，因为心血管疾病是可以预防和可逆的，而目前在单纯的阿尔茨海默病中更普遍的大脑病理学则不是。一些研究人员认为，高血压和心血管疾病在血管性痴呆的前驱阶段比阿尔茨海默病更占主导地位。这是一个重要但未经证实的假设。Moazzami等人6的研究为我们提供了一套敏感的工具（LV质量参数），以帮助回答这个问题，并促进我们对心脏病在痴呆症中的作用的理解。
A more broadly based limitation of all studies to date is the focus on all-cause dementia rather than separately assessing Alzheimer’s disease, vascular dementia, and mixed dementia. These studies are important for determining the specific role played by cardiovascular disease, including LV hypertrophy, in the progression from normal cognitive functioning to dementia. The question is important because cardiovascular disease is preventable and reversible, whereas currently brain pathology more prevalent in purer forms of Alzheimer’s disease is not. Some investigators have argued that hypertension and cardiovascular disease are more dominant in the prodromal stages of vascular dementia than Alzheimer’s disease. This is an important yet unconfirmed hypothesis. The study by Moazzami et al6 gives us a sensitive set of tools (LV mass parameters) to help answer the question and to advance our understanding of the role of heart disease in dementia.