Moment Equations for Partial Filling Capillary Electrophoresis
Moment Equations for Partial Filling Capillary Electrophoresis
复制标题
部分填充毛细管电泳的矩方程
DOI：
10.1002/elps.202100293
复制
发表时间：
2022
期刊：
影响因子：
2.9
通讯作者：
K.
中科院分区：
文献类型：
--
作者：
Miyabe;K.
为部分填充毛细管电泳系统开发了力矩方程，在该系统中，通过球形分子组装体或分子间相互作用发生溶质溶解现象。由于部分填充CE的实验条件根据溶质分子迁移速度与分子组装体或配体分子迁移速度之间的大小关系分为五类，因此利用爱因斯坦扩散方程和随机游走模型系统地建立了每种情况的力矩方程。为了证明矩方程的有效性，将它们应用于部分填充CE行为的分析，作为具体例子，该行为与小溶质分子溶解成球形分子组装体的现象相关。本文只给出了溶质分子迁移速度快于分子组装体迁移速度情况下的模拟结果。关于力矩方程的推导过程和其他情况下的模拟结果的详细说明可以在支持信息中找到。矩方程是应用部分填充毛细管电泳研究球形分子组装体界面溶质渗透动力学和分子间相互作用反应动力学的理论基础。
Moment equations were developed for partial filling CE systems, in which solute dissolution phenomena by spherical molecular assemblies or intermolecular interactions take place. Because experimental conditions of partial filling CE are divided into five categories on the basis of the magnitude relationship between the migration velocity of solute molecules and that of molecular assemblies or ligand molecules, the moment equations were systematically developed for each case by using the Einstein equation for diffusion and the random walk model. In order to demonstrate the effectiveness of the moment equations, they were applied to the analysis of partial filling CE behavior, which is correlated with dissolution phenomena of small solute molecules into spherical molecular assemblies as specific examples. Simulation results only in the case that the migration velocity of solute molecules is faster than that of molecular assemblies were represented in this paper. Detailed explanations about the derivation procedure of the moment equations and the simulation results in other cases can be found in the Supporting Information. The moment equations are theoretical bases for applying partial filling CE to the study on solute permeation kinetics at the interface of spherical molecular assemblies and on reaction kinetics of intermolecular interactions.