Salicylic acid is not a bacterial siderophore: a theoretical study
Salicylic acid is not a bacterial siderophore: a theoretical study
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DOI：
10.1023/a:1009227206890
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发表时间：
2000-06-01
期刊：
影响因子：
3.5
通讯作者：
Ratledge, C
中科院分区：
文献类型：
--
作者：
Chipperfield, JR;Ratledge, C
使用最新可用的程序来计算各种离子的浓度和形态（Pettit， LD和Powell KJ，“SolEq”学术软件，1999），我们计算出在pH 7时，水溶液中存在的游离Fe（III）的量为1.4 x 10(-9) M，而不是通常引用的10(-18)M。在水杨酸存在的情况下（包括在10(-4)M的计算中），铁（III）的溶解度增加到仅9.8 x 10(-9) M，这表明水杨酸盐不能作为铁载体，尽管在缺乏铁的情况下，它作为细胞外产物由一些细菌属产生。在40 mM磷酸盐存在的情况下，pH为7时可溶性Fe（III）浓度降低了10(4)，而且这几乎不受水杨酸盐存在的影响。因此，对于体外或体内生长的微生物，水杨酸不太可能作为铁的增溶剂起作用。同样的结论也适用于2,3-二羟基苯甲酸。
Using a newly available program for calculating the concentrations and speciation of various ions (Pettit, LD & Powell KJ, 'SolEq' Academic Software, 1999), we have calculated that at pH 7 the amount of free Fe(III) present in an aqueous solution is 1.4 x 10(-9) M and not 10(-18) M as is usually quoted. In the presence of salicylic acid, included in the calculations at 10(-4) M, the solubility of Fe(III) is increased to only 9.8 x 10(-9) M suggesting that salicylate is unable to act as a siderophore although it is produced as an extracellular product by several bacterial genera when grown iron deficiently. In the presence of 40 mM phosphate, the soluble Fe(III) concentration is decreased by 10(4) at pH 7 and again this is hardly affected by the presence of salicylate. Thus, for microorganisms grown either in vitro or in vivo, salicylate is unlikely to function as a iron solubilizing agent. The same conclusions may also apply to 2,3-dihydroxybenzoic acid.