APOE genotype influences P3b amplitude and response to smoking abstinence in young adults.
APOE genotype influences P3b amplitude and response to smoking abstinence in young adults.
复制标题
APOE 基因型影响年轻人的 P3b 幅度和对戒烟的反应。
DOI：
10.1007/s00213-021-05763-5
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发表时间：
2021
影响因子：
3.4
通讯作者：
Gilbert,DavidG
中科院分区：
文献类型：
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作者：
Coppens,Ryan;Rabinovich,NorkaE;Kanneganti,Raghuveer;Diggs,HermanA;Wiggs,Kristin;Healey,Travis;Huggenvik,Jodi;Rose,GregoryM;Gilbert,DavidG
有强有力的证据表明尼古丁可以增强认知功能，越来越多的证据表明这种作用在年轻健康的APOE ε4携带者中可能更大。然而，APOE ε4等位基因对慢性吸烟者尼古丁剥夺引起的认知障碍的调节作用尚未用脑指数进行研究。在双刺激听觉oddball任务中，将表现出更大的戒断诱导的P3 b振幅降低。结果尼古丁剥夺显著降低了APOE ε4携带者的P3 b波幅，但APOE-ε3/ε3个体的P3 b波幅无显著性差异，从而消除了尼古丁剥夺前的差异。这可能会影响吸烟模式，尼古丁依赖的风险，以及尼古丁使用对这些人的认知影响。
RationaleThere is strong evidence that nicotine can enhance cognitive functions and growing evidence that this effect may be larger in young healthyAPOEε4 carriers. However, the moderating effects of theAPOEε4 allele on cognitive impairments caused by nicotine deprivation in chronic smokers have not yet been studied with brain indices.ObjectiveWe sought to determine whether young female carriers of theAPOEε4 allele, relative to noncarriers, would exhibit larger abstinence-induced decreases in P3b amplitude during a two-stimulus auditory oddball task.MethodsWe compared parietal P3bs in female chronic smokers with eitherAPOEε3/ε3 (n= 54) or ε3/ε4 (n= 20) genotype under nicotine-sated conditions and after 12–17-h nicotine deprivation.ResultsNicotine deprivation significantly reduced P3b amplitudes inAPOEε4 carriers, but not inAPOE-ε3/ε3 individuals, such that the difference seen prior to nicotine deprivation was eliminated.ConclusionsThe results suggest that subjects with theAPOEε4 allele are more sensitive to nicotine, which could influence smoking patterns, the risk for nicotine dependence, and the cognitive effects of nicotine use in these individuals.