On the genetic basis of face cognition and its relation to fluid cognitive abilities
On the genetic basis of face cognition and its relation to fluid cognitive abilities
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DOI：
10.1111/gbb.12034
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发表时间：
2013-06-01
影响因子：
2.5
通讯作者：
Sommer, W.
中科院分区：
文献类型：
--
作者：
Kiy, A.;Wilhelm, O.;Sommer, W.
事实证明，催产素和多巴胺能系统与社交能力和认知能力高度相关。因此，我们通过应用结构方程模型在多变量研究(N=250)中检验了两个功能基因多态与面孔认知(FC)之间的关联。儿茶酚氧位甲基转移酶(COMT)VAL158MET基因多态性影响COMT酶活性，进而影响前额叶多巴胺浓度。Rs226849是位于催产素受体基因启动子区域的单核苷酸多态，调节基因的表达。通过模拟一般的流动能力因子(由工作记忆和推理定义)和嵌套的Fc因子，我们在控制了也与流动能力相关的Fc的方差后，测试了遗传对Fc的贡献。与之前的几项研究一致，我们发现COMT基因与体液能力(GF)之间存在显著的相关性，但与FC无关。在男性和女性中，催产素基因多态性与生长因子的相关性是相反的。携带C+基因的女性在GF任务中的表现要好于携带C基因的女性。相反，C基因携带者的表现要好于C+基因携带者。OXTR和嵌套FC因子之间没有显著的关联。因此，GF可以完全解释催产素基因多态性与FC之间的关系。这种关系的性别特异性是一个新的发现，需要一个机械的解释。
The oxytocin and the dopaminergic systems have turned out to be highly relevant for social abilities and cognition. Therefore, we examined the association between two functional gene polymorphisms and face cognition (FC) in a multivariate study (N=250) by applying structural equation modeling. The catechol-O-methyltransferase (COMT) val158met polymorphism influences the enzyme activity of COMT, which affects the prefrontal dopamine concentration. The rs226849 is a single-nucleotide polymorphism located in the promoter region of the oxytocin receptor (OXTR) gene, modulating the mRNA expression. By modeling a general fluid ability factor (defined by working memory and reasoning) and nested FC factors, we tested genetic contributions to FC, after controlling for variance in FC that was also associated with fluid abilities. In line with several previous studies, we found a significant association between the COMT genotype and fluid abilities (Gf) but not with FC. The association between the oxytocin polymorphism and Gf was opposite in direction for men and women. Women with the C+ genotype performed better on Gf tasks than those with the C- genotype. Conversely, men with the C- genotype performed better than those with the C+ genotype. There was no significant association between OXTR and the nested FC factor. Therefore, the relationship between the oxytocin polymorphism and FC can be fully accounted for by Gf. The sex specificity of this relationship is a novel finding and warrants a mechanistic explanation.