B16F10 melanoma cell colonization of mouse lung is enhanced by partial pneumonectomy
B16F10 melanoma cell colonization of mouse lung is enhanced by partial pneumonectomy
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DOI：
10.1023/a:1016345627965
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发表时间：
2002-01-01
影响因子：
4
通讯作者：
Rannels, SR
中科院分区：
文献类型：
--
作者：
Brown, LM;Welch, DR;Rannels, SR
外科手术切除肺组织是临床上用于肺转移治疗的一种方法；然而，局部癌症复发是手术后常见的并发症。在各种小型哺乳动物中，左肺切除术(PNX)启动残留肺叶的快速代偿性增生，恢复正常的组织质量、结构和功能。众所周知，PNX治疗后的代偿性肺生长促进了致癌物治疗小鼠肺肿瘤的形成。本研究验证了PNX增强实验性肺转移的假设。用PNX染毒的C57BL/6小鼠在肺代偿生长的不同阶段静脉注射B16F10黑色素瘤细胞。在反应的线性阶段注射B16F10细胞的小鼠肺转移比开胸小鼠多77%至260%(P
Surgical resection of lung tissue is employed clinically as a therapy for pulmonary metastases; however, local cancer recurrence is a frequent post-surgical complication. In a variety of small mammals, left pneumonectomy (PNX) initiates rapid compensatory hyperplasia of the remnant lung lobes restoring normal tissue mass, structure and function. Post-PNX compensatory lung growth is known to promote lung tumor formation in carcinogen-treated mice. The present study tests the hypothesis that PNX enhances experimental metastasis to lung. C57Bl/6 mice subjected to PNX were given an intravenous injection of B16F10 melanoma cells at various stages of compensatory lung growth. Animals injected with B16F10 cells during the linear phase of the response had 77% to 260% more pulmonary metastases than mice subjected to thoracotomy (P