Paper-based microfluidic aptasensors
Paper-based microfluidic aptasensors
复制标题
纸基微流控适体传感器
DOI：
10.1016/j.bios.2020.112649
复制
发表时间：
2020-12-15
影响因子：
12.6
通讯作者：
Cai, Xinxia
中科院分区：
文献类型：
--
作者：
Ming, Tao;Luo, Jinping;Cai, Xinxia
对于原位疾病标志物检测，与传统技术相比，床旁（POC）诊断在速度和成本上具有很大优势。疾病的快速诊断、预后和监测可以显著降低疾病相关的死亡率和创伤。因此，POC诊断设备由于其优异的诊断速度和便携性而受到越来越多的关注。在过去的十年中，纸基微流体适体传感器已经成为一类关键的POC诊断设备，并且已经提出了各种适体传感器来检测各种疾病标志物。然而，大多数适体传感器需要进一步改进才能真正进入市场并广泛使用。因此，迫切需要理清准备适体传感器的关键点和需要投入的方向。本文综述了纸基微流控适体传感器的研究进展。根据输出信号的不同，这些工作可以分为纸基光学适体传感器和纸基电化学适体传感器。重点围绕以下三个方面展开：（1）器件结构的巧妙设计;（2）纳米材料的应用与合成;（3）适体传感器的检测原理。这是一个详细和全面的审查纸基微流体适体传感器。概述了现有适体传感器的研究成果和存在的问题，并对适体传感器的发展方向和前景进行了展望。希望本文的研究能为进一步开发更先进、更有效的纸基微流控适体传感器用于POC疾病标志物的诊断提供参考。
For in-situ disease markers detection, point-of-care (POC) diagnosis has great advantages in speed and cost compared with traditional techniques. The rapid diagnosis, prognosis, and surveillance of diseases can significantly reduce disease-related mortality and trauma. Therefore, increasing attention has been paid to the POC diagnosis devices due to their excellent diagnosis speed and portability. Over the past ten years, paper-based microfluidic aptasensors have emerged as a class of critical POC diagnosis devices and various aptasensors have been proposed to detect various disease markers. However, most aptasensors need further improvement before they can actually enter the market and be widely used. There is thus an urgent need to sort out the key points of preparing the aptasensors and the direction that needs to be invested in. This review summarizes the representative articles in the development of paper-based microfluidic aptasensors. These works can be divided into paper-based optical aptasensors and paper-based electrochemical aptasensors according to their output signals. Significant focus is applied to these works according to the following three parts: (1) The ingenious design of device structure; (2) Application and synthesis of nanomaterial; (3) The detection principle of the proposed aptasensor. This is a detailed and comprehensive review of paper-based microfluidic aptasensors. The accomplishments and shortcomings of the current aptasensors are outlined, the development direction and the future prospective are given. It is hoped that the research in this review can provide a reference for further development of more advanced, more effective paper-based microfluidic aptasensors for POC disease markers diagnosis.