Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis
复制标题
Paip1表明宫颈癌预后不良并促进宫颈癌发生
DOI：
10.4143/crt.2018.544
复制
发表时间：
2019-10-01
影响因子：
4.6
通讯作者：
Lin, Zhenhua
中科院分区：
文献类型：
--
作者：
Li, Nan;Piao, Junjie;Lin, Zhenhua
目的探讨Poly(A)结合蛋白相互作用蛋白1(Paip1)在宫颈癌发生发展中的作用。材料与方法采用免疫组织化学方法检测正常宫颈组织和宫颈癌组织中Paip1的表达。通过体内和体外实验验证Paip1对CC进展的影响。结果发现Paip1在CC中表达上调，与生存期缩短有关。敲除Paip1基因可抑制CC细胞的生长、诱导细胞凋亡和细胞周期停滞，而其过表达则逆转这些作用。体内肿瘤模型证实了Paip1在CC生长中的促肿瘤作用。结论本研究证实了Paip1表达的临床意义，提示Paip1的上调可能是CC的一个潜在的预后和进展的标志物。
PurposeThis study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis.Materials and MethodsThe expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression.ResultsPaip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth.ConclusionAltogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.