In search of the tumour-suppressor functions of BRCA1 and BRCA2
In search of the tumour-suppressor functions of BRCA1 and BRCA2
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DOI：
10.1038/35044000
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发表时间：
2000-11-23
期刊：
影响因子：
64.8
通讯作者：
Livingston, DM
中科院分区：
文献类型：
--
作者：
Scully, R;Livingston, DM
遗传性乳腺癌和卵巢癌综合征可能是由两个肿瘤抑制基因BRCA1和BRCA2中的一个发生功能丧失的胚系突变引起的。1)。每个基因产物与重组/DNA修复蛋白相互作用，参与保护完整的染色体结构。然而，目前还不清楚这些功能在多大程度上特别抑制乳腺癌和卵巢癌。在这里，我们分析了BRCA基因功能的已知情况，并强调了该领域中一些尚未回答的问题。
Hereditary breast and ovarian cancer syndromes can be caused by loss-of-function germline mutations in one of two tumour-suppressor genes, BRCA1 and BRCA2 (ref. 1). Each gene product interacts with recombination/DNA repair proteins in pathways that participate in preserving intact chromosome structure. However, it is unclear to what extent such functions specifically suppress breast and ovarian cancer. Here we analyse what is known of BRCA gene function and highlight some unanswered questions in the field.