Silencing Cofilin‐1 blocks PDGF‐induced proliferation in eutopic endometrium of endometriosis patients
Silencing Cofilin‐1 blocks PDGF‐induced proliferation in eutopic endometrium of endometriosis patients
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DOI：
10.1002/cbin.10093
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发表时间：
2013-08
影响因子：
3.9
通讯作者：
Dan-bo Wang;Yan Xu;Peng Chen;Ying-han Chen;Yan Li
中科院分区：
文献类型：
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作者：
Dan-bo Wang;Yan Xu;Peng Chen;Ying-han Chen;Yan Li
众所周知，血小板衍生生长因子（PDGF）可诱导多种细胞增殖。本研究的目的是研究Cofilin-1（CFL 1）的表达与在位子宫内膜基质细胞（ESC）对PDGF刺激的增殖反应之间是否存在相关性。结果显示，PDGF诱导ESC中CFL 1的表达，并以时间或剂量依赖性方式显著促进ESC的增殖。沉默CFL 1后，PDGF促进ESC增殖的作用明显减弱。这些数据表明PDGF可以诱导ESC中的CFL 1表达。沉默CFL 1阻断了ESC中PDGF诱导的增殖。
Platelet‐derived growth factor (PDGF) is well known to induce proliferation in variety of cells. The aim of this study was to investigate whether there is a correlation between the expression of Cofilin‐1 (CFL1) and the proliferation of eutopic endometrium stromal cells (ESC) in response to PDGF stimulation. Results show that PDGF induced the expression of CFL1 in ESC and promoted proliferation of ESC significantly in a time‐ or dose‐dependent manner. After silencing CFL1, the effect of PDGF on promoting ESC proliferation was significantly decreased. These data demonstrate that PDGF can induce CFL1 expression in ESC. Silencing CFL1 blocks PDGF‐induced proliferation in ESC.