Retinal nerve fiber layer assessment using optical coherence tomography with active optic nerve head tracking
Retinal nerve fiber layer assessment using optical coherence tomography with active optic nerve head tracking
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DOI：
10.1167/iovs.05-0748
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发表时间：
2006-03-01
影响因子：
4.4
通讯作者：
Schuman, JS
中科院分区：
文献类型：
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作者：
Ishikawa, H;Gabriele, ML;Schuman, JS
目的。目的开发眼部运动跟踪光学相干断层扫描(OCT)方法，并评价其对图像配准和神经纤维层(NFL)厚度测量重复性的影响。方法：将能够根据反射率变化跟踪常见眼底特征的系统集成到商用OCT设备(OCT II；Carl Zeiss Meditec，Inc.，Dublin，CA)中，并在健康受试者和青光眼患者上进行测试。连续进行了20次跟踪扫描和20次非跟踪扫描，每只眼每次扫描40幅图像。受试者在三个不同的日子参加了一次会议。生成复合OCT扫描和复合眼底图像以评估眼球跟踪。结果：纳入16名受试者的7只健康眼和9只青光眼。对复合OCT扫描和复合眼底图像的定性评估显示，跟踪时沿边缘和血管几乎没有运动伪影或模糊；然而，当跟踪脱离时，这些结构不太清楚。在有无跟踪的情况下，在任何位置的会话内和会话间NFL测量SD计算中，没有显着的重复性差异。视网膜平均像素SD在跟踪后明显小于未跟踪时(490.9±19.3µm比506.4±31.8µm，P=0.005)。结论成功研制了一套视网膜跟踪系统，并将其集成到一个商用OCT设备中。在这项小样本研究中，跟踪OCT提高了扫描配准的一致性，但不影响NFL厚度测量的重复性。
PURPOSE. To develop an eye-motion-tracking optical coherence tomographic (OCT) method and assess its effect on image registration and nerve fiber layer (NFL) thickness measurement reproducibility.METHODS. A system capable of tracking common fundus features based on reflectance changes was integrated into a commercial OCT unit (OCT II; Carl Zeiss Meditec, Inc., Dublin, CA) and tested on healthy subjects and patients with glaucoma. Twenty successive peripapillary NFL scans were obtained with tracking and 20 without tracking, for 40 images in each session for each eye. Subjects participated in one session on three different days. Composite OCT scans and composite fundus images were generated for assessment of eye tracking. NFL thickness measurement reproducibility was also assessed.RESULTS. Seven healthy and nine glaucomatous eyes of 16 subjects were recruited. A qualitative assessment of composite OCT scans and composite fundus images showed little motion artifact or blurring along edges and blood vessels dining tracking; however, those structures were less clearly defined when tracking was disengaged. There was no significant reproducibility difference with and without tracking in both intra- and intersession NFL measurement SD calculations in any location. The mean retinal pixel SD was significantly smaller with tracking than without (490.9 +/- 19.3 mu m vs. 506.4 +/- 31.8 mu m, P = 0.005, paired t-test).CONCLUSIONS. A retinal-tracking system was successfully developed and integrated into a commercial OCT unit. Tracking OCT improved the consistency of scan registration, but did not influence NFL thickness measurement reproducibility in this small sample study.