Factors associated with macular thickness in the COMET myopic cohort.
Factors associated with macular thickness in the COMET myopic cohort.
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DOI：
10.1097/opx.0b013e318251293a
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发表时间：
2012-05
期刊：
影响因子：
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通讯作者：
COMET Study Group
中科院分区：
文献类型：
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作者：
Harb E;Hyman L;Fazzari M;Gwiazda J;Marsh-Tootle W;COMET Study Group
目的是确定来自近视矫正评估试验 (COMET) 的一组年轻人的黄斑厚度是否与种族、性别、眼轴长度和近视严重程度相关。基线访视 11 年后，387/469 (83%) 受试者返回进行年度访视。除了球面等效屈光不正 (SER) 和轴长 (AL) 的协议特定测量之外，还使用光学相干断层扫描 (RTVue) 进行高分辨率黄斑成像。根据这些扫描，计算出中央（1 毫米）、旁（1-3 毫米）和中心凹周围（3-5 毫米）环形区域的全厚度值。使用单变量和多变量线性回归分析检查性别、种族、AL 和 SER 与黄斑厚度的关联。在具有可用数据的 377 名受试者中（平均年龄=21.0 ±1.3 岁），平均 SER±SD 为 -5.0±1.9 D，平均 AL 为 25.4±0.9 mm。中心凹的平均厚度为252.0±20.1 µm，旁中心凹的平均厚度为315.6±14.0 µm，周围中心凹的平均厚度为284.4±12.9 µm。在根据性别、种族和 AL 进行调整的最佳拟合多变量模型中，所有三个区域的女性黄斑均明显薄于男性 (p<0.0001)，其中中心差异最大（12.8 µm，95% CI：9.2 至 16.4）。种族对中央凹的影响最强，非洲裔美国人、亚洲人、西班牙裔和混合种族的黄斑比白人薄（所有 p 值 < 0.005）。 AL 增加与中央凹稍厚 (p=0.001) 和中央凹旁 (p=0.02) 和中央凹周围 (p< 0.0001) 区域较薄显着相关。在这个不同种族的中度和高度近视人群中，女性和非洲裔美国人的中央凹最薄。年轻人黄斑变薄是否是未来疾病的危险因素仍有待确定。
To determine whether macular thickness is associated with ethnicity, gender, axial length and severity of myopia in a cohort of young adults from the Correction of Myopia Evaluation Trial (COMET). Eleven years after their baseline visit, 387/469 (83%) subjects returned for their annual visit. In addition to the protocol-specific measures of spherical equivalent refractive error (SER) and axial length (AL), high-resolution macular imaging also was performed with Optical Coherence Tomography (RTVue). From these scans, full thickness values for the central (1 mm), para- (1–3 mm), and peri-foveal (3–5 mm) annular regions were calculated. Gender, ethnicity, AL, and SER were examined for associations with macular thickness using univariate and multivariable linear regression analyses. In the 377 subjects with usable data (mean age=21.0 ±1.3 years) the mean SER±SD was −5.0±1.9 D and mean AL was 25.4±0.9 mm. Mean foveal thickness was 252.0± 20.1 µm in the center, 315.6±14.0 µm in the para-fovea, and 284.4±12.9 µm in the peri-fovea. In the best-fit multivariable model that adjusted for gender, ethnicity, and AL, females had significantly thinner maculas than males for all three regions (p<0.0001), with the largest difference in the center (12.8 µm, 95%CI: 9.2 to 16.4). The effect of ethnicity was strongest in the central fovea, with African-Americans, Asians, Hispanics, and mixed ethnic groups thinner maculas than whites (all p-values < 0.005). Increased AL was significantly associated with slightly thicker central foveas (p=0.001) and thinner para- (p=0.02) and peri-foveal (p< 0.0001) regions. In this ethnically diverse cohort of moderate and high myopes, females and African-Americans were found to have the thinnest central foveas. Whether such thinning in the macula as a young adult is a risk factor for future disease remains to be determined.