The International Workshop on Meibomian Gland Dysfunction: Executive Summary
The International Workshop on Meibomian Gland Dysfunction: Executive Summary
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DOI：
10.1167/iovs.10-6997a
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发表时间：
2011-03-01
影响因子：
4.4
通讯作者：
Sullivan, David A.
中科院分区：
文献类型：
--
作者：
Nichols, Kelly K.;Foulks, Gary N.;Sullivan, David A.
睑板腺功能障碍（MGD）很可能是全世界干眼病的主要原因。尽管这种疾病影响着数百万人的健康和福祉，但对于 MGD 的定义、分类、诊断或治疗尚未达成全球共识。为了达成这样的共识，非营利组织泪膜和眼表协会（TFOS；http://www.tearfilm.org）发起了睑板腺功能障碍国际研讨会（www.tearfilm.org/mgdworkshop/index.html）。研讨会的目标是： ● 对健康和疾病中的睑板腺结构和功能进行循证评估； ● 对 MGD 的定义和分类有一个当代的理解； ● 评估 MGD 的诊断、评估和严重程度分级的方法； ● 制定 MGD 管理和治疗的建议； ● 制定适当的临床试验设计规范，以评估治疗 MGD 的药物干预措施； ● 制定适当的临床试验设计规范，以评估 MGD 治疗的药物干预措施； ● 总结MGD未来研究的建议。MGD研讨会的报告历时两年多才完成，于2010年完成。这项工作涉及来自世界各地的50多名领先的临床和基础研究专家。这些被分配到小组委员会的参与者审查了已发表的数据并检查了支持证据的水平。小组委员会的报告在所有研讨会参与者之间分发，并在公开论坛上提交，并以互动方式进行讨论。
Meibomian gland dysfunction (MGD) may well be the lead-ing cause of dry eye disease throughout the world. Although this condition affects the health and well-being of millions of people, there is no global consensus on the definition, classification, diagnosis, or therapy for MGD. To achieve such a consensus, the Tear Film and Ocular Surface Society (TFOS; http://www. tearfilm. org), a nonprofit organization, launched the International Workshop on Meibomian Gland Dysfunction (www. tearfilm. org/mgdworkshop/index. html). The objectives of the workshop were to:● conduct an evidence-based evaluation of meibomian gland structure and function in health and disease;● develop a contemporary understanding of the definition and classification of MGD;● assess methods of diagnosis, evaluation, and grading of the severity of MGD;● develop recommendations for the management and therapy of MGD;● develop appropriate norms of clinical trial design to evaluate pharmaceutical interventions for the treatment of MGD; and● create a summary of recommendations for future research in MGD.The report of the Workshop on MGD, which required more than 2 years to complete, was finalized in 2010. This effort involved more than 50 leading clinical and basic research experts from around the world. These participants, who were assigned to subcommittees, reviewed published data and examined the levels of supporting evidence. Subcommittee reports were circulated among all workshop participants, presented in open forum, and discussed in an interactive manner.