Age- and Level-Dependence of Fatty Infiltration in Lumbar Paravertebral Muscles of Healthy Volunteers
Age- and Level-Dependence of Fatty Infiltration in Lumbar Paravertebral Muscles of Healthy Volunteers
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DOI：
10.3174/ajnr.a4596
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发表时间：
2016-04-01
影响因子：
3.5
通讯作者：
Ulbrich, E. J.
中科院分区：
文献类型：
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作者：
Crawford, R. J.;Filli, L.;Ulbrich, E. J.
背景和目的：椎旁肌肉质量与年龄相关的正常下降对于患者的疾病和风险识别具有重要的参考价值。本研究旨在建立健康成年志愿者椎旁(多裂和竖脊)肌体积和脂肪含量随年龄和椎体水平变化的关系。材料和方法：在这项前瞻性研究中，80名健康志愿者(每10岁男女各10名，年龄20-62岁)用Dixon 3T磁共振成像测量腰椎水平L1-L5的多裂和竖脊脂肪信号分数和体积。采用Bonferroni校正后的方差分析比较了不同亚组之间的脂肪信号分数和体积。结果：女性脂肪信号分数(17.8%，10.7%)高于男性(14.7%+/-7.8%；P<；.001)，且随年龄增长而增加。女性多裂肌和竖脊肌体积(565.4±83.8 cm(3))小于男性(811.6±98.9 cm(3)；P<；.001)，且与年龄无关。左右椎旁肌之间或L1、L2和L3腰椎水平之间的脂肪信号分数没有差异。脂肪信号分数在L5最高(女性，31.9%+/-9.3%；男性，25.7%+/-8.0%；P<；.001)。L4的脂肪信号分数与腰椎总脂肪信号分数的相关性最好(女性r=0.95；男性r=0.92，P<；0.001)。男女L1-L4腰椎多裂肌的总脂肪信号分数高于竖脊肌(P<；.001)。结论：在20-62岁的健康志愿者中，腰椎旁肌脂肪含量随年龄增长而增加，与体积无关。女性、腰椎低节段和多裂肌受影响最大。有必要对年轻和年长的受试者进行进一步的研究，以及椎旁肌脂肪浸润性病变的功能影响。
BACKGROUND AND PURPOSE: Normative age-related decline in paravertebral muscle quality is important for reference to disease and risk identification in patients. We aimed to establish age- and vertebral level-dependence of paravertebral (multifidus and erector spinae) muscle volume and fat content in healthy adult volunteers.MATERIALS AND METHODS: In this prospective study multifidus and erector spinae fat signal fraction and volume at lumbar levels L1-L5 were measured in 80 healthy volunteers (10 women and men per decade, 20-62 years of age) by 2-point Dixon 3T MR imaging. ANOVA with post hoc Bonferroni correction compared fat signal fraction and volume among subgroups. Pearson and Spearman analysis were used for correlations (P < .05).RESULTS: Fat signal fraction was higher in women (17.8% 10.7%) than men (14.7% +/- 7.8%; P < .001) and increased with age. Multifidus and erector spinae volume was lower in women (565.4 +/- 83.8 cm(3)) than in men (811.6 +/- 98.9 cm(3); P < .001) and was age-independent. No differences in fat signal fraction were shown between the right and left paravertebral muscles or among the L1, L2, and L3 lumbar levels. The fat signal fraction was highest at L5 (women, 31.9% +/- 9.3%; men, 25.7% +/- 8.0%; P < .001). The fat signal fraction at L4 correlated best with total lumbar fat signal fraction (women, r = 0.95; men, r = 0.92, P < .001). Total fat signal fraction was higher in the multifidus compared with erector spinae muscles at L1-L4 for both sexes (P < .001).CONCLUSIONS: Lumbar paravertebral muscle fat content increases with aging, independent of volume, in healthy volunteers 20-62 years of age. Women, low lumbar levels, and the multifidus muscle are most affected. Further study examining younger and older subjects and the functional impact of fatty infiltrated paravertebral muscles are warranted.