COMPARE: a web accessible tool for investigating mechanisms of cell growth inhibition
COMPARE: a web accessible tool for investigating mechanisms of cell growth inhibition
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DOI：
10.1016/s1093-3263(01)00126-7
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发表时间：
2002-01-01
影响因子：
2.9
通讯作者：
Svetlik, PA
中科院分区：
文献类型：
--
作者：
Zaharevitz, DW;Holbeck, SL;Svetlik, PA
10多年来，美国国家癌症研究所（NCI）一直在测试化合物抑制培养中人类肿瘤细胞系生长的能力（NCI筛选）。肯·保罗的作品[J. Natl. Cancer Inst.81（1989）1088]证明，具有相似的细胞生长抑制机制的化合物在NCI筛选中显示出相似的活性模式。这一观察结果被开发成一种名为COMPARE的算法，并已成功用于预测各种化合物的机制。最近，这种方法已被扩展到将化合物抑制细胞生长的模式与NCI筛选中细胞系中分子实体（例如基因表达）的测量相关联。COMPARE方法和相关数据可在发育治疗学项目（DTP）网站（http：//dtp.nei.nih.gov/）上免费获得。将解释和演示在这些网页上使用比较的例子。出版社：Elsevier Science Inc.
For more than 10 years the National Cancer Institute (NCI) has tested compounds for their ability to inhibit the growth of human tumor cell lines in culture (NCI screen). Work of Ken Paull [J. Natl. Cancer Inst. 81 (1989) 1088] demonstrated that compounds with similar mechanism of cell growth inhibition show similar patterns of activity in the NCI screen. This observation was developed into an algorithm called COMPARE and has been successfully used to predict mechanisms for a wide variety of compounds. More recently, this method has been extended to associate patterns of cell growth inhibition by compounds with measurements of molecular entities (such as gene expression) in the cell lines in the NCI screen. The COMPARE method and associated data are freely available on the Developmental Therapeutics Program (DTP) web site (http://dtp.nei.nih.gov/). Examples of the use of COMPARE on these web pages will be explained and demonstrated. Published by Elsevier Science Inc.