Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway
Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway
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DOI：
10.1016/j.bbr.2013.07.052
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发表时间：
2013-09-15
影响因子：
2.7
通讯作者：
Zheng, Dong
中科院分区：
文献类型：
--
作者：
Wu, Wei;Yu, Xiao;Zheng, Dong
川芎嗪因其神经保护作用而被用于治疗多种神经系统疾病。在这里，我们证明，管理川芎嗪有效地扭转记忆缺陷东莨菪碱诱导。此外，川芎嗪保护突触后蛋白质合成并恢复cAMP/PKA/CREB通路信号传导缺陷。本研究不仅探讨了川芎嗪对突触的作用，而且为川芎嗪治疗痴呆的可能性提供了新的证据。(C)2013爱思唯尔有限公司版权所有。
Tetramethylpyrazine is used in the treatment of many neurological diseases because of its neuroprotective effect. Here, we demonstrate that administration of tetramethylpyrazine effectively reverses memory deficits induced by scopolamine. Moreover, tetramethylpyrazine preserves postsynaptic protein synthesis and restores cAMP/PKA/CREB pathway signaling deficits. Our study not only explores the actions of tetramethylpyrazine on synapses, but also provides novel evidence for the possible therapeutic use of tetramethylpyrazine in dementia. (C) 2013 Elsevier B.V. All rights reserved.