Cumulative Lifetime Marijuana Use and Incident Cardiovascular Disease in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Cumulative Lifetime Marijuana Use and Incident Cardiovascular Disease in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
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DOI：
10.2105/ajph.2017.303654
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发表时间：
2017-04-01
影响因子：
12.7
通讯作者：
Sidney, Stephen
中科院分区：
文献类型：
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作者：
Reis, Jared P.;Auer, Reto;Sidney, Stephen
目标。研究大麻对心血管和脑血管事件发生的影响。方法。参与者是来自年轻人冠状动脉风险发展研究的 5113 名基线（1985-1986）年龄在 18 至 30 岁的成年人，他们被跟踪了超过 25 年。我们利用每 2 至 5 年检查中收集的重复评估来估计一生中累积的大麻暴露量。主要结局是 2013 年心血管疾病 (CVD) 事件。结果。总共 84% (n = 4286) 报告了吸食大麻的历史。在中位 26.9 年（131 990 人年）期间，我们发现了 215 起 CVD 事件，包括 62 起中风或短暂性脑缺血发作、104 例冠心病病例和 50 例 CVD 死亡。与不吸食大麻相比，累积寿命和近期吸食大麻与 CVD、中风或短暂性脑缺血发作、冠心病或 CVD 死亡率没有关联。按年龄、性别、种族或 CVD 家族史分层时，吸食大麻与 CVD 无关。结论。累积寿命和近期吸食大麻均与中年 CVD 发病率无关。
Objectives. To investigate the effects of marijuana in the development of incident cardiovascular and cerebrovascular outcomes.Methods. Participants were 5113 adults aged 18 to 30 years at baseline (1985-1986) from the Coronary Artery Risk Development in Young Adults study, who were followed for more than 25 years. We estimated cumulative lifetime exposure to marijuana using repeated assessments collected at examinations every 2 to 5 years. The primary outcome was incident cardiovascular disease (CVD) through 2013.Results. A total of 84% (n = 4286) reported a history of marijuana use. During a median 26.9 years (131 990 person-years), we identified 215 CVD events, including 62 strokes or transient ischemic attacks, 104 cases of coronary heart disease, and 50 CVD deaths. Compared with no marijuana use, cumulative lifetime and recent marijuana use showed no association with incident CVD, stroke or transient ischemic attacks, coronary heart disease, or CVD mortality. Marijuana use was not associated with CVD when stratified by age, gender, race, or family history of CVD.Conclusions. Neither cumulative lifetime nor recent use of marijuana is associated with the incidence of CVD in middle age.