Instantaneous carbon-carbon bond formation using a microchannel reactor with a catalytic membrane
Instantaneous carbon-carbon bond formation using a microchannel reactor with a catalytic membrane
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DOI：
10.1021/ja066697r
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发表时间：
2006-12-20
影响因子：
15
通讯作者：
Kitamori, Takehiko
中科院分区：
文献类型：
--
作者：
Uozumi, Yasuhiro;Yamada, Yoichi M. A.;Kitamori, Takehiko
在具有聚合物钯络合物膜的微通道反应器中实现瞬时催化碳-碳键形成反应。在微通道内，非交联聚合物结合的膦和四氯钯酸铵分别溶解于层流的有机相和水相的界面处，通过自组装络合作用构建催化膜。钯催化的偶联反应的芳基卤化物和芳基硼酸进行使用的微通道反应器，在4秒的保留时间内，在限定的通道区域给出定量的联芳基的产量。
Instantaneous catalytic carbon−carbon bond forming reactions were achieved in a microchannel reactor having a polymeric palladium complex membrane. The catalytic membrane was constructed inside the microchannel via self-assembling complexation at the interface between the organic and aqueous phases flowing laminarly, where non-cross-linked polymer-bound phosphine and ammonium tetrachloropalladate dissolved, respectively. A palladium-catalyzed coupling reaction of aryl halides and arylboronic acids was performed using the microchannel reactor to give quantitative yields of biaryls within 4 s of retention time in the defined channel region.