A prognostic scoring system based on clinical features of intrahepatic cholangiocarcinoma: the Fudan score
A prognostic scoring system based on clinical features of intrahepatic cholangiocarcinoma: the Fudan score
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DOI：
10.1093/annonc/mdq650
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发表时间：
2011-07-01
影响因子：
50.5
通讯作者：
Chen, Y. -X.
中科院分区：
文献类型：
--
作者：
Jiang, W.;Zeng, Z. -C.;Chen, Y. -X.
背景资料：本研究的目的是提出一个适用于肝内胆管细胞癌（ICC）的临床预后评分系统，并评估美国癌症联合委员会（AJCC）第7版staging system.Patients和方法的预后有效性：回顾性单变量和多变量生存分析进行了344例ICC谁接受肝切除术。根据独立预测因子建立一个简单的临床预后评分系统（复旦评分）。结果：在训练集中，血清碱性磷酸酶水平、糖链抗原19-9水平、肿瘤边界类型、肿瘤大小和肝内肿瘤数目是ICC生存的独立预测因素，并被纳入复旦评分。344例患者分为4个亚组，低、中、高和极高风险组的5年总生存率分别为48.6%、25.6%、10.3%和0.0%。复旦评分的区分能力优于AJCC分期系统，并且在未切除患者中得到了良好的应用。结论：基于临床因素的复旦评分可以为ICC患者提供相对准确的预后预测，无论切除状态如何。
Background: The objectives of this study were to propose a clinical prognostic scoring system applicable for intrahepatic cholangiocarcinoma (ICC) and to evaluate the prognostic validity of the American Joint Committee on Cancer (AJCC) 7th edition staging system.Patients and methods: Retrospective univariate and multivariate survival analyses were conducted for 344 patients with ICC who underwent hepatectomy. A simple clinical prognostic scoring system (Fudan score) was developed based on the independent predictors. The prognostic validity was assessed in 74 patients with unresected tumors and compared with the AJCC 6th and 7th edition systems.Results: In the training set, serum alkaline phosphatase level, carbohydrate antigen 19-9 level, tumor boundary type, tumor size, and number of intrahepatic tumors were independent predictive factors of survival in ICC and were incorporated into the Fudan score. Three hundred forty-four patients were categorized into four subsets with 5-year overall survival rates of 48.6%, 25.6%, 10.3%, and 0.0% for low-, intermediate-, high-, and extremely high-risk groups, respectively. The discriminative ability of the Fudan score was better than that of the AJCC staging system and well applied in the unresected patient set.Conclusions: A Fudan score based on clinical factors may provide a relatively accurate prognostic prediction for ICC patients regardless of resection status.