Synergy between genetic and tissue engineering: creating an artificial salivary gland
Synergy between genetic and tissue engineering: creating an artificial salivary gland
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DOI：
10.1111/j.1600-0757.2006.00160.x
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发表时间：
2006-01-01
影响因子：
18.6
通讯作者：
Tran, SD
中科院分区：
文献类型：
--
作者：
Baum, BJ;Tran, SD
本文讨论了通过基因工程和组织工程的协同作用来创造人工唾液腺。人工唾液腺是治疗头颈部癌症患者唾液功能减退和唾液腺泡细胞丢失的必要手段。它的基本成分是极化上皮细胞层，可生物降解的基质，以及基质管腔表面的细胞外基质蛋白涂层。
The article discusses the creation of an artificial salivary gland through the synergy between genetic and tissue engineering. An artificial salivary gland is necessary to remedy salivary hypofunction and loss of salivary acinar cells in patients suffering from cancer of the head and neck. Its essential elements are polarized ephithelial cell layer, biodegradable substratum, and a coating of an extracellular matrix protein on the substratum's luminal surface.