IDENTIFICATION OF THE CONSTANT CHROMOSOME REGIONS INVOLVED IN HUMAN HEMATOLOGIC MALIGNANT DISEASE
IDENTIFICATION OF THE CONSTANT CHROMOSOME REGIONS INVOLVED IN HUMAN HEMATOLOGIC MALIGNANT DISEASE
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DOI：
10.1126/science.7079737
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
ROWLEY, JD
中科院分区：
文献类型：
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作者：
ROWLEY, JD
特定的一致染色体易位在某些人类白血病和淋巴瘤中经常观察到。对于髓系白血病，恒定的重组是：慢性髓系白血病的9号长臂至22号染色体，急性髓母细胞白血病的21号长臂至8号染色体，急性早幼粒细胞白血病的17号长臂至15号染色体。三个相关的易位见于伯基特淋巴瘤和B细胞急性淋巴细胞白血病；在每个例子中，8号染色体与2号、14号或22号染色体相连。对影响8号染色体的一个复杂易位进行分析，指出8号染色体易位是染色体重排的关键常数。分析这些染色体易位位点的DNA，而不是每次易位的相互作用，似乎是初步研究中最有成效的重点。各种免疫球蛋白位点位于染色体2、14和22上，这些染色体经常参与伯基特淋巴瘤和B细胞急性淋巴细胞白血病的易位。
Specific consistent chromosome translocations are regularly observed in certain human leukemias and lymphomas. For the myeloid leukemias, the constant recombinants are: the long arm of 9 to chromosome 22 in chronic myeloid leukemia, the long arm of 21 to chromosome 8 in acute myeloblastic leukemia, and the long arm of 17 to chromosome 15 in acute promyelocytic leukemia. Three related translocations are seen in Burkitt lymphoma and B cell acute lymphocytic leukemia; in each one, chromosome 8 is involved with chromosome 2, 14, or 22. Analysis of a complex translocation affecting chromosome 8 and indicates that the translocation of chromosome 8 to chromosome is the critical constant rearrangement. The analysis of the DNA at the translocation sites of these chromosomes, rather than the reciprocal of each translocation, appears to be the most productive focus for initial study. The various immunoglobulin loci are located on chromosomes 2, 14, and 22, the chromosomes regularly involved in translocations in Burkitt lymphoma and B cell acute lymphocytic leukemia.