Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration
Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration
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DOI：
10.1002/mds.20040
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发表时间：
2004-07-01
影响因子：
8.6
通讯作者：
Landwehrmeyer, GB
中科院分区：
文献类型：
--
作者：
Henkel, K;Karitzky, J;Landwehrmeyer, GB
使用 [C-11]PK 11195（外周苯二氮卓受体结合位点的配体）进行正电子发射断层扫描 (PET)，为体内激活的小胶质细胞成像提供了机会。因此，该工具可用于显示神经变性过程中小胶质细胞激活的发生。使用氟脱氧葡萄糖 (FDG) 和 [C-11]PK 11195 PET 对一名临床诊断为皮质基底节变性 (CBD) 和左侧症状的患者进行了研究。我们发现，基底神经节以及右侧颞叶和顶叶皮层的相应区域存在明显的右侧半球代谢减退和不对称小胶质细胞激活。 [C-11]PK 11195 PET 表明小胶质细胞激活参与了 CBD 的发病机制。 (C) 2004 年运动障碍协会。
Positron emission tomography (PET) using [C-11]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [C-11]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [C-11]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD. (C) 2004 Movement Disorder Society.