POSTOPERATIVE REACTIONS OF RATS AFTER ORTHOTOPIC LIVER-TRANSPLANTATION - A MODEL FOR THE HUMAN RESPONSE - A HISTOLOGICAL AND BIOCHEMICAL-STUDY
POSTOPERATIVE REACTIONS OF RATS AFTER ORTHOTOPIC LIVER-TRANSPLANTATION - A MODEL FOR THE HUMAN RESPONSE - A HISTOLOGICAL AND BIOCHEMICAL-STUDY
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DOI：
10.1159/000128317
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发表时间：
1982-01-01
影响因子：
1.6
通讯作者：
BROLSCH, C
中科院分区：
文献类型：
--
作者：
ANDRZEJEWSKI, W;BROLSCH, C
在尽管MHC [主要组织相容性复合体]存在差异但仍拒绝（DA/LEW）或接受（LEW/DA）移植物的品系组合以及与MHC身份（BH/LEW）相结合的品系组合中研究了原位肝移植大鼠的术后反应。组织形态学研究显示血清转氨酶水平升高与肝排斥反应之间存在高度相关性。在所有菌株组合中碱性磷酸盐水平均增加。在特定的大鼠品系，特别是DA/LEW，严重的移植排斥反应发生。这种组合可能是一个合适的模型比较移植后的反应，在移植的人肝。
Postoperative reactions in rats with orthotopic liver grafts were studied in strain combinations which rejected (DA/LEW) or accepted (LEW/DA) the graft despite differences in the MHC [major histocompatibility complex] and in a combination with MHC identity (BH/LEW). Histomorphological studies revealed a high correlation between increased serum transminase levels and liver rejection. There was an increased alkaline phosphate level in all strain combinations. In specific rat strains, in particular DA/LEW, severe graft rejection occurred. This combination is probably a suitable model for comparison with the posttransplantation reaction in the grafted human liver.