Exercise treatment for depression - Efficacy and dose response
Exercise treatment for depression - Efficacy and dose response
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DOI：
10.1016/j.amepre.2004.09.003
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发表时间：
2005-01-01
影响因子：
5.5
通讯作者：
Chambliss, HO
中科院分区：
文献类型：
--
作者：
Dunn, AL;Trivedi, MH;Chambliss, HO
背景：本研究于1998年至2001年进行，并于2002年和2003年进行分析。目的是测试（1）运动是否是治疗轻度至中度重度抑郁症（MDD）的有效方法，以及（2）运动与抑郁症状减轻的剂量-反应关系。设计：该研究是随机2x2析因设计，加上安慰剂对照。所有的运动都是在有监督的实验室环境中进行的，年龄在20至45岁之间的成年人（n = 80）被诊断为轻度至中度MDD。参与者被随机分配到四个有氧运动治疗组中的一个，这些治疗组的总能量消耗不同（7.0 kcal/kg/周或17.5 kcal/kg/周）和频率（3天/周或5天/周）或运动安慰剂对照（3天/周灵活性运动）。17.5-kcal/kg/周剂量符合公共卫生对体力活动的建议，并被称为“公共卫生剂量”（PHD）。7.0 kcal/kg/周的剂量被称为“低剂量”（LD）。主要结果测量：主要结果是17项汉密尔顿抑郁量表（HRSD 17）的评分。PHD组第12周校正的平均HRSD 17评分较基线降低47%，LD组降低30%，对照组降低29%。运动频率在12 weeks.Conclusions：有氧运动的剂量符合公共卫生建议是一种有效的治疗轻度至中度严重程度的抑郁症。较低剂量与安慰剂效应相当。(C)2005年美国预防医学杂志。
Background: This study, conducted between 1998 and 2001 and analyzed in 2002 and 2003. designed to test (1) whether exercise is an efficacious treatment for mild to moderate major depressive disorder (MDD), and (2) the dose-response relation of exercise and reduction in depressive symptoms.Design: The study was a randomized 2x2 factorial design, plus placebo control.Setting/Participants: All exercise was performed in a supervised laboratory setting with adults (n = 80) aged 20 to 45 years diagnosed with mild to moderate MDD.Intervention: Participants were randomized to one of four aerobic exercise treatment groups that varied total energy expenditure (7.0 kcal/kg/week or 17.5 kcal/kg/week) and frequency (3 days/week or 5 days/week) or to exercise placebo control (3 days/week flexibility exercise). The 17.5-kcal/kg/week dose is consistent with public health recommendations for physical activity and was termed "public health dose" (PHD). The 7.0-kcal/kg/week dose was termed "low dose" (LD).Main Outcome Measures: The primary outcome was the score on the 17-item Hamilton Rating Scale for Depression (HRSD17).Results: The main effect of energy expenditure in reducing HRSD17 scores at 12 weeks was significant. Adjusted mean HRSD17 scores at 12 weeks were reduced 47% from baseline for PHD, compared with 30% for LD and 29% for control. There was no main effect of exercise frequency at 12 weeks.Conclusions: Aerobic exercise at a dose consistent with public health recommendations is an effective treatment for MDD of mild to moderate severity. A lower dose is comparable to placebo effect. (C) 2005 American Journal of Preventive Medicine.