Sleep disturbance mediates the association between psychological distress and immune status among HIV-positive men and women on combination antiretroviral therapy
Sleep disturbance mediates the association between psychological distress and immune status among HIV-positive men and women on combination antiretroviral therapy
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DOI：
10.1016/s0022-3999(02)00501-9
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发表时间：
2003-03-01
影响因子：
4.7
通讯作者：
Schneiderman, N
中科院分区：
文献类型：
--
作者：
Cruess, DG;Antoni, MH;Schneiderman, N
目的：探讨hiv阳性男性和女性心理困扰、主观睡眠障碍与免疫状态的关系。方法：通过社区广告和医生推荐招募57名无艾滋病相关疾病且目前正在接受抗逆转录病毒联合治疗的参与者（41名男性，16名女性）。参与者完成了事件影响量表（IES）来评估心理困扰的症状，并完成了匹兹堡睡眠质量指数（PSQI）来评估过去一个月的睡眠质量。还从清晨的血液样本中评估t淋巴细胞亚群。结果：报告更大心理困扰的参与者也报告更明显的睡眠中断。较高水平的焦虑和更严重的睡眠障碍也与较低的t细胞毒性/抑制因子（CD3+CD8+）细胞计数显著相关。通径分析显示，抑郁水平与CD3+CD8+细胞计数之间的关联是由较差的主观睡眠质量介导的。结论：这些发现表明，心理困扰可能通过影响睡眠质量来影响免疫系统。(C) 2003爱思唯尔科学有限公司版权所有。
Objectives: This study examined the relationship between psychological distress, subjective sleep disturbance and immune status among HIV-positive men and women. Methods: Fifty-seven participants (41 men, 16 women) without AIDS-related illness and currently on combination antiretroviral therapy were recruited through community advertisement and physician referral. Participants completed the Impact of Events Scale (IES) to assess symptoms of psychological distress and the Pittsburgh Sleep Quality Index (PSQI) to assess quality of sleep over the past month. T-lymphocyte subpopulations were also assessed from early morning blood samples. Results: Participants reporting greater psychological distress also reported more pronounced sleep disruption. Higher levels of distress and greater sleep disturbance were also significantly related to lower T-cytotoxic/suppressor (CD3+CD8+) cell counts. Path analysis revealed that the association between distress level and CD3+CD8+ cell counts was mediated by poorer subjective sleep quality. Conclusions: These findings suggest that psychological distress may impact upon the immune system through its effects on sleep quality. (C) 2003 Elsevier Science Inc. All rights reserved.