On the environment of ionizable groups in globular proteins.
On the environment of ionizable groups in globular proteins.
复制标题
关于球状蛋白中可电离基团的环境。
DOI：
10.1016/0022-2836(84)90394-2
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发表时间：
1984
影响因子：
5.6
通讯作者：
Honig,B
中科院分区：
文献类型：
--
作者：
Rashin,AA;Honig,B
36种蛋白质中可电离基团的环境以溶剂可及性、盐桥形成和氢键为特征。考虑了我们的结果对掩埋的可电离基团的质子化状态的可能的影响，并得出了对蛋白质的建模研究有用的模式。最有趣的发现是，平均每个蛋白质有两个完全被掩埋的可电离基团，其中至少20%不形成盐桥。然而，所有埋藏的可电离基团都与中性极性基团形成氢键。
The environment of ionizable groups in 36 proteins is characterized in terms of solvent-accessibility, salt-bridge formation and hydrogen-bonding. Possible implications of our results as to the protonation state of buried ionizable groups are considered and patterns useful for model building studies on proteins are derived. The most interesting finding is that there are on average two completely buried ionizable groups per protein of which at least 20% do not form saltbridges. However, all buried ionizable groups form hydrogen bonds with neutral polar groups.