Novel object exploration in mice: Not all objects are created equal
Novel object exploration in mice: Not all objects are created equal
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DOI：
10.1016/j.beproc.2011.12.004
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发表时间：
2012-03-01
影响因子：
1.3
通讯作者：
Chemero, Anthony
中科院分区：
文献类型：
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作者：
Heyser, Charles J.;Chemero, Anthony
对象探索是行为科学中越来越受欢迎的实验范式。我们已经开始对小鼠进行一系列研究，专门研究影响这项测试中行为的参数。本研究旨在探讨客体类型对客体探索测验成绩的影响。更具体地说，成年雄性C57 BL/6 J小鼠使用可以攀爬的物体（CLIMB）或只能触摸的物体（TOUCH）进行训练和测试。结果表明，活动的对象的呈现，与对象类型与这些变化的一些相互作用的影响。C57小鼠探索可以攀爬的物体比只能触摸的物体明显更长，并且使用只能触摸的物体观察到更快的习惯化。在两组小鼠中均观察到稳健的识别记忆，然而，与TOUCH组中的小鼠相比，CLIMB组中的小鼠表现出显著更大的辨别指数。两者合计，这些研究结果表明，对象的选择是至关重要的，它建议特别注意的功能（负担得起的）属性的对象将在未来的研究中使用。(C)2011爱思唯尔有限公司版权所有。
Object exploration is an increasingly popular experimental paradigm in behavioral sciences. We have begun a series of studies with mice specifically looking at the parameters that influence behaviors in this test. The aim of the present study was to examine the effect of object type on performance in the object exploration test. More specifically, adult male C57BL/6J mice were trained and tested using objects that could be climbed (CLIMB) or with those that could only be touched (TOUCH). The results show that activity is affected by the presentation of objects, with object type interacting with some of these changes. C57 mice explored objects that can be climbed over significantly longer than objects that can only be touched and a more rapid habituation was observed using objects that could only be touched. Robust recognition memory was observed in both groups of mice, however mice in the CLIMB group exhibited a significantly greater discrimination index compared to mice in the TOUCH group. Taken together, these findings demonstrate that the selection of objects is of critical importance and it is recommended that special attention be given to the functional (affordant) properties of the objects to-be-used in future studies. (C) 2011 Elsevier B.V. All rights reserved.