NOTCH1 mutations are associated with high CD49d expression in chronic lymphocytic leukemia: link between the NOTCH1 and the NF-κB pathways
NOTCH1 mutations are associated with high CD49d expression in chronic lymphocytic leukemia: link between the NOTCH1 and the NF-κB pathways
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DOI：
10.1038/leu.2017.296
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发表时间：
2018-03-01
期刊：
影响因子：
11.4
通讯作者：
Zucchetto, A.
中科院分区：
文献类型：
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作者：
Benedetti, D.;Tissino, E.;Zucchetto, A.
在慢性淋巴细胞白血病（CLL）中，NOTCH 1的稳定突变影响高达10-15%的病例，与预后不良、疾病进展和化疗难治性相关。NOTCH 1突变在12三体CLL中显著过度表达，12三体CLL是一种经常表达CD 49 d的疾病亚群，CD 49 d是极晚期活化-4整合素的α 4链，是一种众所周知的微环境相互作用的关键调节因子，也是CLL中的负性趋化因子。在本研究中，通过分析1180例CLL的广泛队列，我们观察到NOTCH 1突变的存在与CD 49 d的表达之间存在非常强的相关性（P
In chronic lymphocytic leukemia (CLL), stabilizing mutations of NOTCH1, affecting up to 10-15% of cases, have been associated to poor prognosis, disease progression and refractoriness to chemotherapy. NOTCH1 mutations are significantly overrepresented in trisomy 12 CLL, a disease subset frequently expressing CD49d, the alpha 4 chain of the very-late-activation-4 integrin, a well-known key regulator of microenviromental interactions, and negative prognosticator in CLL. In the present study, by analysing a wide cohort of 1180 CLL, we observed a very strong association between the presence of NOTCH1 mutations and the expression of CD49d (P