EFFICACY AND SAFETY OF HYDROLYZED COW MILK AND AMINO ACID-DERIVED FORMULAS IN INFANTS WITH COW MILK ALLERGY
EFFICACY AND SAFETY OF HYDROLYZED COW MILK AND AMINO ACID-DERIVED FORMULAS IN INFANTS WITH COW MILK ALLERGY
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DOI：
10.1016/s0022-3476(95)70111-7
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发表时间：
1995-10-01
影响因子：
5.1
通讯作者：
TURJANMAA, K
中科院分区：
文献类型：
--
作者：
ISOLAURI, E;SUTAS, Y;TURJANMAA, K
目的：确定蛋白水解物或氨基酸衍生配方奶粉对牛奶过敏婴儿的抗原性、营养充足性和促生长功效。研究设计：在74名患有牛奶过敏的特应性儿童中，对几种蛋白质水解物或氨基酸衍生的配方奶粉的β-乳球蛋白含量和皮肤反应性进行了分级，这是通过双盲、安慰剂对照的挑战来证明的。一项9个月的前瞻性随访研究包括22名平均年龄为6个月的婴儿（95%置信区间，4至7），这些人被喂食广泛水解乳清配方奶粉（W-e组）和23名平均年龄为7岁的婴儿（95%置信区间，4至7）个月，谁得到了氨基酸衍生的公式（AA组），结果：两种配方奶粉在临床和生化上都是耐受的。与母乳喂养的对照组婴儿相比，W-e组血浆中必需氨基酸的平均浓度较低，但AA组较高（a = 0.001），各组体重变化趋势不同（p = 0.09）和长度（p = 0.006），AA组在随访期间生长得到促进;在最初的几个月内，它是恒定的，然后在W-e组中比率逐渐下降。在两组中，特应性湿疹显著地和进行性地改善，血清总IgE和牛奶特异性IgE浓度呈下降趋势，证明了两种配方奶粉的有效性。结论：广泛水解配方奶粉对大多数婴儿安全有效;氨基酸衍生配方奶粉可能更适合多种食物过敏的婴儿，特别是对维持正常生长。
Objective: To determine the antigenicity, nutritional adequacy, and growth-promoting efficacy of protein hydrolysate or amino acid-derived formulas in infants with cow milk allergy.Study design: Several protein hydrolysate or amino acid-derived formulas were graded for beta-lactoglobulin content and skin reactivity in 74 atopic children with cow milk allergy proved by a double-blind, placebo-controlled challenge, A randomized, prospective follow-up study of 9 months included 22 infants with a mean age of 6 months (95% confidence interval, 4 to 7), who were fed an extensively hydrolyzed whey formula (group W-e), and 23 infants with a mean age of 7 (95% confidence interval, 4 to 7) months, who were given an amino acid-derived formula (group AA),Results: Both formulas were clinically and biochemically tolerated, The mean concentration of essential amino acids in plasma was lower in group W-e but higher in group AA compared with values for breast-fed control infants (a = 0.001), There was a different trend between the groups in weight (p = 0.09) and length (p = 0.006), Growth was promoted in group AA during the follow-up; it was constant during the first months, followed by a gradual decline in rate in group W-e, In both groups, atopic eczema improved significantly and progressively, and a downward trend was found in serum total and milk-specific IgE concentrations, proving the efficacy of both formulas,Conclusions: Extensively hydrolyzed formulas are safe and effective for most infants; an amino acid-derived formula may be preferable for infants with multiple food allergies, especially for the maintenance of normal growth.