Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study.
Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study.
复制标题
DOI：
10.1186/1471-244x-11-179
复制
发表时间：
2011-11-17
期刊：
影响因子：
4.4
通讯作者：
Campbell IC
中科院分区：
文献类型：
--
作者：
Brooks SJ;Barker GJ;O'Daly OG;Brammer M;Williams SC;Benedict C;Schiöth HB;Treasure J;Campbell IC
先前对神经性厌食症（AN）患者的磁共振成像（MRI）研究显示了大脑结构的差异。本研究旨在通过研究不同程度的食欲抑制对脑容量的影响，初步扩展这一数据。对14例AN患者（8例RAN和6例BPAN）和21例HC患者进行了基于体素的形态测量（VBM），校正了总颅内容积、年龄、BMI、受教育年限。脑容量与饮食限制之间的相关性使用社会科学统计软件包（SPSS）进行。与HC相比，AN患者右侧背外侧前额叶皮质（DLPFC）增加，右侧前岛皮质、双侧海马旁回、左侧梭状回、左侧小脑和右侧后扣带体积减少。与BPAN相比，RAN减少了左侧眶额皮质、右侧岛叶前部皮质、双侧海马旁回和左侧小脑。年龄与HC患者右侧DLPFC体积呈负相关，而AN患者无相关；饮食限制和BMI预测了AN患者右侧DLPFC体积57%的方差。在AN中，在食欲、体感和自上而下控制脑区发现脑容量差异。区域GMV的差异可能与食欲抑制水平有关，但它们是状态还是特征尚不清楚。然而，这些离散的脑容量差异为饮食失调患者的进一步结构和功能研究提供了候选脑区域。
Previous Magnetic Resonance Imaging (MRI) studies of people with anorexia nervosa (AN) have shown differences in brain structure. This study aimed to provide preliminary extensions of this data by examining how different levels of appetitive restraint impact on brain volume. Voxel based morphometry (VBM), corrected for total intracranial volume, age, BMI, years of education in 14 women with AN (8 RAN and 6 BPAN) and 21 women (HC) was performed. Correlations between brain volume and dietary restraint were done using Statistical Package for the Social Sciences (SPSS). Increased right dorsolateral prefrontal cortex (DLPFC) and reduced right anterior insular cortex, bilateral parahippocampal gyrus, left fusiform gyrus, left cerebellum and right posterior cingulate volumes in AN compared to HC. RAN compared to BPAN had reduced left orbitofrontal cortex, right anterior insular cortex, bilateral parahippocampal gyrus and left cerebellum. Age negatively correlated with right DLPFC volume in HC but not in AN; dietary restraint and BMI predicted 57% of variance in right DLPFC volume in AN. In AN, brain volume differences were found in appetitive, somatosensory and top-down control brain regions. Differences in regional GMV may be linked to levels of appetitive restraint, but whether they are state or trait is unclear. Nevertheless, these discrete brain volume differences provide candidate brain regions for further structural and functional study in people with eating disorders.