Molecular aspects of phospholipase A2 activation.
Molecular aspects of phospholipase A2 activation.
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磷脂酶 A2 激活的分子方面。
DOI：
10.1007/978-1-4613-0651-1_6
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发表时间：
1990
影响因子：
--
通讯作者：
Bell,JD
中科院分区：
文献类型：
--
作者：
Biltonen,RL;Heimburg,TR;Lathrop,BK;Bell,JD
可溶性磷脂酶 A2 的一个显着特征是它们在脂质-水界面处被激活的倾向。1这些酶在聚集磷脂底物中的活性比单体底物高得多。此外，活性很大程度上受聚集脂质状态的影响。我们对磷脂酶 A2 的兴趣集中在激活过程的机制以及该过程中脂质结构和/或动力学作用的物理基础。
A striking characteristic of soluble phospholipases A2is their tendency to become activated at a lipid-water interface.1The activity of these enzymes is much greater with aggregated phospholipid substrates than with monomeric substrates. Furthermore, the activity is heavily influenced by the state of the aggregated lipids. Our interests in phospholipase A2are focussed on the mechanism of the activation process and the physical basis of the role of lipid structure and/or dynamics in that process.