EFFECT OF NEUROVESTIBULAR STIMULATION ON AUTONOMIC REGULATION
EFFECT OF NEUROVESTIBULAR STIMULATION ON AUTONOMIC REGULATION
复制标题
DOI：
10.1007/bf01818894
复制
发表时间：
1995-10-01
影响因子：
5.8
通讯作者：
BIAGGIONI, I
中科院分区：
文献类型：
--
作者：
COSTA, F;LAVIN, P;BIAGGIONI, I
与恶心和呕吐相关的病症，例如晕动病或药物副作用，通常与副交感神经激活和交感神经退缩一致的临床表现有关。因此，可以假设前庭刺激有助于交感神经的退缩。为了验证这一假设，我们对 5 名 24-33 岁的正常志愿者进行了热量前庭刺激研究，同时通过放置在腓神经中的针电极直接监测肌肉交感神经活动。以450ml/min的流速和37℃的水冲洗耳朵。水温以7℃的间隔依次降低，直至出现无法忍受的副作用或达到16℃的温度。所有受试者都会出现眼球震颤，但心率、血压、肌肉交感神经活动和血浆去甲肾上腺素水平在热量刺激期间或之后没有显着变化，即使受试者感到头晕和恶心。通过肌肉交感神经活动或血浆去甲肾上腺素测量，没有在任何受试者中观察到交感神经退缩的证据。总之，我们发现选择性前庭刺激并不伴随交感神经系统功能的显着变化。特别是，没有观察到交感神经退缩。可以说，缺乏交感神经刺激是对与热量刺激相关的症状的不充分反应。
Conditions associated with nausea and vomiting, such as motion sickness or side effects of medications, are commonly associated with a clinical picture consistent with parasympathetic activation and sympathetic withdrawal. It can be postulated, therefore, that vestibular stimulation contributes to sympathetic withdrawal. To test this hypothesis five normal volunteers, 24-33 years old, were studied during caloric vestibular stimulation while monitoring muscle sympathetic nerve activity directly through a needle electrode placed in a peroneal nerve. The ear was irrigated with water at a flow rate of 450 ml/min and 37 degrees C. The water temperature was sequentially lowered by 7 degrees C intervals until intolerable side effects developed or a temperature of 16 degrees C was reached. Nystagmus was induced in all subjects, but heart rate, blood pressure, muscle sympathetic nerve activity and plasma norepinephrine levels did not change significantly during or after caloric stimulation, even when the subjects felt dizzy and nauseated. No evidence of sympathetic withdrawal was observed in any subject either by muscle sympathetic nerve activity or plasma norepinephrine measurements. In conclusion, we have found that selective vestibular stimulation is not accompanied by significant changes in the sympathetic nervous system function. In particular, no sympathetic withdrawal was observed. It could be argued that lack of sympathetic stimulation is an inadequate response to the symptoms associated with caloric stimulation.